The expression and prognostic significance of circadian gene NR1D1/2 in patients with gastric cancer

Zheng, Zhixue; Cai, Xuan; Bi, Jing; Liu, Ya Qi

doi:10.21203/rs.3.rs-2560341/v1

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Water avoidance stress (WAS) in mice recapitulates psychological stress transfer from the brain to gut changes 19,20 . We used 6 weeks SPF male C57BL/6J mice and randomly divided these mice into the WAS group and the Sham group.…”

Section: Stress Impairs Mitochondria and Triggers Dysbiosismentioning

confidence: 99%

Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway

Duan

2024

Preprint

View full text Add to dashboard Cite

Psychological stress can lead to gut dysbiosis, yet the precise mechanisms underlying the transfer of stress signals from the brain to the gut remain elusive. Here we describe a new pathway that conveys stress from brain to gut and trigger dysbiosis. Acute stress activates hypothalamic-pituitary-adrenal (HPA) axis and release corticotropin-releasing factor (CRF) to elevate colonocytes’ CRF receptors 1 (CRHR1) expression, which damages mitochondrial ultrastructure and respiration function, as well impairs colon epithelium hypoxia, thereby shifts gut microbiota dominant strains from obligate anaerobes to facultative anaerobes. Blocking CRHR1 or activating mitochondria conferred resilience to stress induced mitochondria damaging and epithelium hypoxia impairing. Furthermore, we corroborated these findings by observing significant changes in serum CRF levels, colonocytes’ mitochondria and gut microbiota in patients with irritable bowel syndrome (IBS). These results suggest that the CRF-CRHR1-mitochondria pathway plays a pivotal role in stress-induced gut dysbiosis that could be therapeutically targeted for stress-induced gastrointestinal diseases.

show abstract

Section: Stress Impairs Mitochondria and Triggers Dysbiosismentioning

confidence: 99%

Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway

Duan

2024

Preprint

View full text Add to dashboard Cite

show abstract

The Circadian Clock as a Potential Biomarker and Therapeutic Target in Gastrointestinal Cancers

Barati,

Saffar,

Mehrabadi

et al. 2024

CPD

View full text Add to dashboard Cite

The circadian clock consists of a hierarchical multi-oscillator network of intracellular and intercellular mechanisms throughout the body that contributes to anticipating metabolic activity and maintaining system homeostasis in response to environmental cues and intrinsic stimuli. Over the past few years, genetic variations of core clock genes have been associated with cancer risk in several epidemiological studies. A growing number of epidemiological research studies have demonstrated a direct correlation between the disturbance of circadian rhythms and the growth of tumors, indicating that shift workers are more susceptible to malignancies of the colon, prostate, ovarian, breast, lung, and liver. One of the most related cancers with circadian rhythm is Gastrointestinal (GI) cancer, which is a leading cause of cancer-related mortality nowadays. The aim of this review was to demonstrate the effect of the clock gene network on the growth of GI cancer, providing molecular targets for GI cancer treatment, possible prognostic biomarkers, and guidance for treatment choices.

show abstract

Natural Compounds for Preventing Age-Related Diseases and Cancers

Ki,

Youn,

Kim

et al. 2024

IJMS

View full text Add to dashboard Cite

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external and internal signs of aging manifest in various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. Additionally, cancer, like aging, is a complex disease that arises from the accumulation of various genetic and epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for aging and cancer development. Natural compounds and herbal medicines have gained significant attention for their potential in preventing age-related diseases and inhibiting cancer progression. These compounds demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects as well as circadian clock regulation. This review explores age-related diseases, cancers, and the potential of specific natural compounds in targeting the key features of these conditions.

show abstract

The expression and prognostic significance of circadian gene NR1D1/2 in patients with gastric cancer

Cited by 3 publications

References 33 publications

Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway

Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway

The Circadian Clock as a Potential Biomarker and Therapeutic Target in Gastrointestinal Cancers

Natural Compounds for Preventing Age-Related Diseases and Cancers

Contact Info

Product

Resources

About