The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma

Abstract

Head and neck cancers are the seventh most common forms of cancer worldwide, encompassing a wide range of tumors arising from numerous anatomic subsites including the nasal cavity, paranasal sinuses, nasopharynx, oral cavity, lips, oropharynx, hypopharynx, and larynx. 1 Head and neck squamous cell carcinoma (HNSCC) is the most frequent histological type, accounting for more than 90% of head and neck cancers. 2,3 The incidence of HNSCC is approximately 1,000,000 patients diagnosed worldwide, and about

Diagnostic and prognostic value ofcircRNAsexpression in head and neck squamous cell carcinoma: A meta‐analysis

“…Finally, 55 articles that involved details regarding 56 unique circRNAs and 5,576 HNSCC cases (all cases were reliably diagnosed via histopathological analysis) were included in this meta‐analysis. To be specific, we included 31 diagnostic studies (from 23 articles 25–47 ), 38 prognostic studies (from 38 articles 25–30,48–79 ), and 27 clinical‐pathological feature‐related studies(from 26 articles 28,29,43,47,48,50,51,53,55,56,58,63–68,70–74,76–79 ).…”

“…Finally, 55 articles that involved details regarding 56 unique circRNAs and 5,576 HNSCC cases (all cases were reliably diagnosed via histopathological analysis) were included in this metaanalysis. To be specific, we included 31 diagnostic studies (from 23 articles ), 38 prognostic studies (from 38 articles [25][26][27][28][29][30] ), and ). As shown in Table 2, we performed a prognostic meta-analysis of 38 relevant studies that assessed the association between circRNAs and OS, and 7 studies that assessed the association between circRNAs and DFS.…”

hsa_circ_0000264 promotes tumor progression via the hsa‐let‐7b‐5p/HMGA2 axis in head and neck squamous cell carcinoma

“…Therefore, investigating the biomarkers for HNSCC has always been a prioritized research area. Many circRNAs have been identified as biomarkers in HNSCC, such as hsa_circ_0016148, hsa_circ_0032822, and hsa_circ_0000140 (Peng et al, 2020; Shen, Wang, et al, 2021; Zhang et al, 2021). These biomarkers may affect proliferation, migration, and invasion and are correlated with poor prognosis in HNSCC.…”

Circular RNA Controls Tumor Occurrence and Development via Cell Cycle Regulation

“…3 Circular RNAs are differentially expressed in a variety of cancers, and their clinical significance as potential diagnostic markers has been shown for different malignancies, such as liver cancer, 4 colorectal cancer, 5 glioblastoma, 6 and head and neck squamous cell carcinoma. 7 In addition, many studies have used survival analysis to evaluate the relationship between the expression level of circRNAs in different tumors and the survival rates of patients, reflecting the value of circRNAs in judging tumor prognosis. [8][9][10] Circular RNAs primarily play a role in tumors by acting as competing endogenous RNA (ceRNA) sponge miRNAs to attenuate the miRNA repression of target genes.…”