The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy—The University of Iowa Experience

Intensity-Modulated Radiotherapy for Oral Cavity Squamous Cell Carcinoma: Patterns of Failure and Predictors of Local Control

“…Gomez et al (11) described 35 patients treated with postoperative IMRT for OC malignancies with 3-year estimates of local-regional progression-free survival and OS of 77% and 74%, respectively. Yao et al (13) reported on 55 patients with cancers of the OC, with 2-year rates of LC, LRC, and OS of 85%, 82%, and 68%, respectively. Studer and colleagues (12) described a series of OC cancer patients treated with IMRT, including 28 in the postoperative setting, with 2-year local control of 92%.…”

“…The median number of involved nodes was 2 (range, 0-7). The majority of patients underwent ipsilateral (13) or bilateral (1) modified radical neck dissection. Ten patients (35%) did not undergo neck dissection because of clinically N0 neck with definitive indications for postoperative RT (n = 3), primary disease believed to be early stage (n = 1), medical comorbidities (n = 3), or unspecified reasons (n = 3).…”

“…Prior clinical studies have suggested excellent outcomes for intensity-modulated RT (IMRT) when used in the head-and-neck region, usually in series dominated by oropharyngeal and nasopharyngeal cancers (6)(7)(8)(9)(10). Fewer studies have specifically evaluated IMRT for tumors of the OC (11)(12)(13)(14), in which target delineation is made more complicated by surgically distorted anatomy. We present a series of patients treated with IMRT for SCC of the OC with a focus on patterns of local-regional failure, issues related to timing of RT, and prognostic features of recurrence.…”

Intensity‐modulated radiation therapy

“…After a median follow-up of 17.1 months, the 2-year local recurrence-free survival was 85%. One marginal failure occurred in the contralateral lower neck outside of the radiation field [21].…”

Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells

“…1,3,4 Surgical excision can result in complications, and the use of conventional radiotherapy may cause an oral cavity disorder, resulting in reduced patient survival time. 5 Because local carcinoma recurrences are common and current treatments can result in significant problems, alternative therapeutic approaches are warranted. 6 Thermal therapy is emerging as a promising alternative strategy that is simple to perform and is advantageous as an alternative treatment for certain malignancies.…”