The “Fas counterattack” is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability

Houston, Aileen; Michael-Robinson, Julie M.; Walsh, Michael D.; Cummings, Margaret C.; Ryan, Aideen E.; Lincoln, Doug; Pandeya, Nirmala; Jass, Jeremy R.; Radford‐Smith, Graham; O’Connell, Joe

doi:10.1016/j.humpath.2007.06.010

Cited by 21 publications

(19 citation statements)

References 29 publications

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“…Similarly to our studies, many authors also found no correlations between the respective clinicohistopathological parameters, such as histological differentiation grade [14,15,[18][19][20][21], Dukes' classification [14,20], tumor histological type [20] and location [14,17,19,20], depth of infiltration [15] and the presence of local lymph node involvement or distant metastases [19]. It would be interesting to consider whether the changes in FasL protein and Fas receptor expression would be useful prognostic factors for colorectal carcinoma patients.…”

Section: Discussionsupporting

confidence: 82%

“…Nozoe et al [17] not only observed FasL correlation with metastases to lymph nodes and distant organs, but also with Dukes' classification, superficial tumor type, depth of infiltration and lymphatic permeation of the colorectal carcinoma, but not with vascular invasion. In other studies, the expression of FasL protein was found to correlate with histological type [18,19], high level of microsatellite instability (MSI-H) [18,20] and patients' survival [19].…”

Section: Discussionmentioning

confidence: 86%

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Fas/FasL expression in colorectal cancer. An immunohistochemical study.

Pryczynicz

Guzińska‐Ustymowicz²,

Kemonä³

2010

Folia Histochem Cytobiol.

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Materials and methodsTissue samples. The study group consisted of 50 patients with colorectal carcinoma, operated on in the Surgical Department of the J. Sniadecki Hospital in Bialystok. Colorectal carcinoma specimens FOLIA HISTOCHEMICA ET CYTOBIOLOGICA Vol. 48, No. 3, 2010 pp. 425-429 Fas/FasL expression in colorectal cancer. An immunohistochemical study Anna Pryczynicz, Katarzyna Guziñska-Ustymowicz and Andrzej Kemona Department of General Pathomorphology, Medical University of Bia³ystok, Bia³ystok, Poland Abstract: The objective of the current study was to assess the expression of Fas ligand (FasL) and Fas receptor (FasR) as the proteins of the post-mitochondrial apoptotic pathway in colorectal carcinoma and to investigate correlations between their expression and chosen clinico-pathological parameters. The protein expression was analyzed in 50 colorectal carcinoma patients, using the immunohistochemical method. Reaction for FasR was weak in 75.5% and strong in 24.5% of the study patients, as compared to normal glandular epithelium where FasR expression was strong in 100% of cases. On the other hand, FasL expression was found to be weak in 30% and strong in 70% of colorectal cancer patients, as compared to its lack in 100% of normal colorectal epithelium. Statistical analysis showed strong expression of FasL was found to correlate statistically significantly with vascular invasion (p=0.005). No correlations of FasL and FasR expression in the main mass of tumor was found between other clinic-pathological parameters. Fas ligand and Fas receptor appeared to be of little usefulness as prognostic factors for different groups of colorectal carcinoma patients. However, these proteins could become good therapeutic targets for colorectal carcinoma since their expression differs distinctly between normal intestinal epithelium and cancer cells, and known is the mechanism by which cancer cells escape death via apoptosis-inducing Fas/FasL pathway disorders.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 86%

Fas/FasL expression in colorectal cancer. An immunohistochemical study.

Pryczynicz

Guzińska‐Ustymowicz²,

Kemonä³

2010

Folia Histochem Cytobiol.

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“…We found that MMR defects correlated positively with an enhanced immune response and metal ion binding, whereas RAF alterations correlated with activation of cellular processes and thyroid hormone generation. Many tumor-infiltrating lymphocytes are present in MSI+ tumors, along with activated CD8+ cytotoxic T cells [26,27] . Furthermore, tumor-specific peptides generated by MSI may be involved in antitumor immune responses and may be useful in the diagnosis and treatment of patients with MSI+ colorectal cancers [27] .…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling: Canonical molecular changes and clinicopathological features in sporadic colorectal cancers

Kim¹,

Kim²,

Roh³

et al. 2008

WJG

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“…Other authors confirm the abundance of CD8+ TILs and granzyme-positive cells as well as improved clinical outcome in patients with MSI-H compared to MSS colorectal cancers [98][99][100] . In addition, a positive correlation between apoptosis rates and higher TIL number has been described, a finding which could perhaps help to explain the improved prognosis seen in patients with MSI-H compared to MSS tumors [98,101] . Studies on T-regs such as FOXP3 and CD25+ have recently been undertaken [102] .…”

Section: The Invasive Front Of Colorectal Cancer: Msimentioning

confidence: 93%