The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Shabana, N.A.; Hasnain, Shahida

doi:10.1016/j.gene.2015.07.087

Cited by 22 publications

(13 citation statements)

References 38 publications

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“…In addition, there was a correlation between FABP2 levels and high SBP and DBP. These results contradict previously reported findings . However, FABP2 has been reported to be related to increased cardiovascular risk in dyslipidemic diabetic patients, and an association between FABP2 Ala54Thr genotypes and central arterial stiffness and blood pressure in subjects with high cardiorespiratory fitness has been reported …”

Section: Discussioncontrasting

confidence: 99%

“…The role of the Ala54Thr polymorphism in many diseases, including obesity, diabetes, and insulin resistance, has been assessed in different ethnicities, but the results of associations across different populations are contradictory and inconsistent. 20 The present study showed a lack of association between either the Ala54Thr polymorphism or FABP2 levels and FBG, HbA1c, and HOMA-IR. These results are in accordance with the findings of a study performed on a Saudi population, in which the Ala54Thr polymorphism was not associated with the risk of T2DM and related traits.…”

Section: Discussioncontrasting

confidence: 67%

“…There was a positive correlation between FABP2 levels and BMI, and negatively correlation with HDL‐C. A previous meta‐analysis revealed a significant association between this polymorphism and obesity . An association with obesity was also reported in a Greek Caucasian population .…”

Section: Discussionmentioning

confidence: 62%

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Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Khattab

Abo-Elmatty

Ghattas

et al. 2016

Journal of Diabetes

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Background: Intestinal fatty acid-binding protein 2 (FABP2) is expressed in enterocytes and binds saturated and unsaturated long-chain fatty acids. The FABP2 Ala54Thr polymorphism has been reported to effect lipid metabolism. The aim of the present study was to assess the relationship between this polymorphism and peripheral atherosclerosis combined with type 2 diabetes mellitus (T2DM) in an Egyptian population. Methods: The study was performed on 100 T2DM patients with peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism, whereas serum FABP2 levels were determined using ELISA. Fasting blood glucose, fasting serum insulin concentrations, HbA1c, lipid profile, body mass index (BMI) and systolic and diastolic blood pressure (SBP and DBP, respectively) were determined. Results: There was a higher frequency of the Thr54 allele among the patient group (P = 0.002). In Ala54/Thr54 heterozygotes and carriers of the rare Thr54/Thr54 genotype, there were significant increases in BMI and FABP2. Those with the Thr54/Thr54 genotype had significantly decreased high-density lipoprotein cholesterol (HDL-C) concentrations; in addition, those with the Thr54/Thr54 genotype had significantly higher SBP and DBP than subjects with the Ala54/Ala54 and Ala54/Thr54 genotypes. There was a positive correlation between FABP2 levels and BMI, SBP and DBP, and a negative correlation with HDL-C. Conclusions: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 67%

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Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Khattab

Abo-Elmatty

Ghattas

et al. 2016

Journal of Diabetes

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“…According to the Global Burden of Disease Study, in terms of obesity, it ranked 9th out of 188 countries [19]. Pakistan faced a lot of health challenges during a decade long war on terror [20]. LEP gene p. N103K mutation has not been investigated in the Pakistani subjects previously.…”

Section: Introductionmentioning

confidence: 99%

The p. N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan

Shabana

Hasnain

2016

Biol Res

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BackgroundObesity is a complex disorder and has been increasing globally at alarming rates including Pakistan. However, there is scarce research on understanding obesity genetics in Pakistan. Leptin is a hormone secreted by adipocytes in response to satiety and correlates with body weight. Any mutations in the LEP gene have an adverse effect on energy regulation pathway and lead to severe, early onset obesity. To date, only eight mutations have been described in the LEP gene of which p. N103K is one.MethodsWe aimed to analyze the prevalence of this mutation in Pakistani subjects. A total of 475 subjects were genotyped by PCR–RFLP analysis and their serum profiling was done.ResultsResults showed that this mutation was present only in one male child with early onset obesity (10 year). He had very low serum leptin levels suggestive of functional impact of the mutation. The prevalence of such mutations is, however, low due to the drastic effects on the energy regulation.ConclusionIn conclusion, LEP gene mutations contribute significantly to the monogenic forms of obesity and are important due to the availability of treatment options. Such mutations may exert their effect by directly affecting energy regulation pathway and are more prominent in the early stages of life only.

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“…Estima-se que a frequência do p.Ala54Thr seja em torno de 30% na população em geral 17 . No entanto, Canani et al encontraram uma frequência do alelo Thr54 de 25% em uma amostra de 493 indivíduos brasileiros com diabetes mellitus tipo 2 (DM2) 18 , similar à frequência encontrada em um estudo realizado com indivíduos obesos graves (43,7% Ala54Thr e 3,6% Thr54Thr -frequência alélica de 0, 25) 19 .…”

Section: Polimorfismo Ala54thr Do Gene Fatty Acid-binding Proteinunclassified

Polimorfismo Ala54Thr do gene fatty acid-bindingprotein-2 (FABP -2): uma revisão bibliográfica

Kops

Vivan

Horvath

et al. 2016

cbr

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The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Cited by 22 publications

References 38 publications

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

The p. N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan

Polimorfismo Ala54Thr do gene fatty acid-bindingprotein-2 (FABP -2): uma revisão bibliográfica

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