The features of complex therapy of bacterial vaginosis in pregnant women with cervical incompetence

Konkov, D.G.; Adamchuk, N.V.; Klivak, Vitaliy

doi:10.18370/2309-4117.2020.54.55-62

2020

DOI: 10.18370/2309-4117.2020.54.55-62

|View full text |Cite

The features of complex therapy of bacterial vaginosis in pregnant women with cervical incompetence

D.G. Konkov

N.V. Adamchuk

Vitaliy Klivak

Abstract: Objective of the study: to study the clinical and laboratory efficacy of the Femivag® (contains Lactobacillus gasseri, Lactobacillus rhamnosus) drug in the complex treatment of bacterial vaginosis (BV) in pregnant women with high risk of preterm birth.Materials and methods. 42 pregnant women at the 16–18 weeks of gestation with cervical dysfunction and BV diagnosed before cervical pessary installation were examined and treated. All patients were assessed the dynamics of symptoms severity, performed PCR testі w… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2022

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The modern features of optimal therapy of cervical neoplasia on the background of bacterial vaginosis

Таран

Rud

Булавенко

et al. 2021

Self Cite

View full text Add to dashboard Cite

Research objective: to evaluate the effectiveness of vaginal decametoxinum in preparation for cervix excision (conization) in women with HSIL (cervical intraepithelial neoplasia (CIN) II) against the background of infection with high-risk human papilloma virus (HPV) in bacterial vaginosis (BV) and effectiveness of vaginal gel with decametoxinum and hyaluronic acid to improve repair in the postoperative period.Materials and methods. 60 women with HSIL (CIN II) were examined against the background of high-risk oncogenic HPV infection and BV, who underwent loop cervix excision (conization). The main group (n = 30) on the eve of surgery was prescribed BV therapy with decametoxinum solution and oral metronidazole for up to 7 days, after cervical excision used vaginal gel with decametoxinum and hyaluronic acid for 14 days. The control group (30 patients) used oral metronidazole for 7 days for the BV treatment.Visual cervix inspection was performed by colposcopy. Vaginal biocenosis was assessed by PCR. Elimination of oncogenic HPV strains was assessed by PCR.Results. Decametoxinum in the combination therapy of HSIL (CIN II) caused faster and complete epithelialization of the wound surface than standard therapy (relative risk (RR) 0.27, 95% CI 0.10 – 0.71, p = 0.008). 3 months after decametoxinum use was determined by a significant increase in cases of vaginal microbiota normalization (RR 0.30, 95% CI 0.09 – 0.98, p = 0.047), an increase in the lactobacilli number in vaginal secretions (RR 0.31, 95% CI 0.11 – 0.84, p = 0.02). There was a statistically significant effect of decametoxinum on the oncogenic HPV elimination (RR 0.22, 95% CI 0.05 – 0.94, p = 0.04) after 6 months of combination therapy. No side effects of decametoxinum were noted either during therapy or at a later date.Conclusions. Vaginal use of decametoxinum before and after loop cervix excision in women with HSIL (CIN II) on the background of high-risk HPV and BV showed acceleration of cervical reparative processes, pronounced antimicrobial effect, elimination of oncogenic HPV and safety.

show abstract

The modern features of optimal therapy of cervical neoplasia on the background of bacterial vaginosis

Таран

Rud

Булавенко

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

The Clinical Assessment of the Cervical Perforated Pessary for the Prevention of Preterm Labor in Women With Prior Preterm Births

Konkov

Zhurauleu²,

Honcharenko

et al. 2022

Wiad Lek

View full text Add to dashboard Cite

The aim: The assessment of clinical effectiveness the cervical perforated pessary (CPP) used for prevention of preterm labor. Materials and methods: Caucasian women with prior SPL who were randomized to receive a CPP (clinical group) or without pessary (control group) was conducted at the Vinnytsya maternal hospital №1, from 2014 through 2018. Eligible women were those referred to the institution for a diagnosis of cervical incompetence between 16 weeks and 18 weeks +6 days. Outcomes will be PTL before 28, 32, 35, and 37 weeks of gestation; a composite of poor perinatal outcomes. Results: The incidence of SPL at less than 37 weeks of gestation was occurred in 14,1% vs 29,3% (RR 0,48, 95% CI, 0,23-0,99), lower rate of SPL at less than 35 weeks of gestation (RR 0,30, 95% CI, 0,10-0,88), longer gestational age (Dif. -1,4, 95% CI, -2,30 to -0,50), higher birth weight (Dif. -197,9, 95% CI, -307,6 to -88,15), lower incidence of adverse composite perinatal outcome (RR 0,28, 95% CI, 0,1-0,81) from the pessary and control group respectively. The participants pessary clinical group had a higher rate than the control group of increased vaginal discharge (RR 1,31, 95% CI, 1,01-1,69), but no differences in pelvic discomfort (RR 0,54, 95% CI, 0,14-2,18), chorioamnionitis (RR 0,30, 95% CI, 0,06-1,44). Conclusions: The women with prior SPL use of a CPP, resulted in a lower rate of SPL. The component in the successful results of preventive strategy SPL is consideration of vaginal microbiota and role of special trained staff for installation and care cervical pessary.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The features of complex therapy of bacterial vaginosis in pregnant women with cervical incompetence

Cited by 2 publications

References 24 publications

The modern features of optimal therapy of cervical neoplasia on the background of bacterial vaginosis

The modern features of optimal therapy of cervical neoplasia on the background of bacterial vaginosis

The Clinical Assessment of the Cervical Perforated Pessary for the Prevention of Preterm Labor in Women With Prior Preterm Births

Contact Info

Product

Resources

About