The fibrinogen-albumin ratio as a novel prognostic factor for elderly patients with osteosarcoma

Fu, Yang; Yu, Yang; Zhou, Yi; Li, Tong; Xie, Yizhou; Wang, Yehui; Ran, Qiang; Chen, Yiming; Fan, Xiaohong

doi:10.1097/md.0000000000034926

Cited by 2 publications

References 39 publications

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Prognostic and clinicopathological significance of fibrinogen-to-albumin ratio (FAR) in patients with breast cancer: a meta-analysis

Wang,

Shen

2024

World J Surg Onc

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Background The fibrinogen-to-albumin ratio (FAR) has been extensively studied for its role in predicting the prognosis of breast cancer (BC) patients; however, existing findings are conflicting. Therefore, this meta-analysis was conducted to identify the significance of FAR in predicting BC prognosis. Methods We searched PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure databases until May 25, 2024. The value of FAR for predicting overall survival (OS) and disease-free survival (DFS) in BC was examined by calculating the combined hazard ratios (HRs) and 95% confidence intervals (CIs). Correlations between FAR and clinicopathological factors were analyzed using combined odds ratios (ORs) and 95% CIs. Results Eight studies involving 4094 patients were included in this work. As shown by our combined data, increased FAR significantly predicted poor OS (HR = 2.84, 95% CI = 1.83–4.39, p < 0.001) and poor DFS (HR = 2.43, 95% CI = 1.66–3.58, p < 0.001) of BC. Moreover, the combined data showed that increased FAR was significantly correlated with age ≥ 50 years (OR = 2.04, 95% CI = 1.37–3.04, p < 0.001), stage III cancer (OR = 1.53, 95% CI = 1.04–2.27, p = 0.033), and the presence of lymph node metastases (OR = 1.33, 95% CI = 1.11–1.61, p = 0.002). Nonetheless, FAR was not significantly associated with tumor size, ER/PR/HER-2 status, or lymphovascular invasion in patients with BC. Conclusion In this meta-analysis, higher FAR was significantly associated with unfavorable OS and DFS in patients with BC and significantly correlated with several features predictive of cancer development in BC. Supplementary Information The online version contains supplementary material available at 10.1186/s12957-024-03506-2.

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Prognostic and clinicopathological significance of fibrinogen-to-albumin ratio (FAR) in patients with breast cancer: a meta-analysis

Wang,

Shen

2024

World J Surg Onc

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Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with bacterial infection

Fu,

Zhang,

Wang

et al. 2024

Preprint

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Objective: To investigate the clinical significance of neutrophil-to-lymphocyte ratio (NLR), fibrinogen-to-albumin ratio (FAR), and red blood cell distribution width (RDW) in pulmonary tuberculosis (PTB) combined with bacterial infection of the lung. Metheds: 74 patients with pulmonary tuberculosis combined with bacterial infection of the lung attending the Sixth People's Hospital of Nantong City from January 2021 to December 2024 were selected as the infected group, and 96 patients with simple pulmonary tuberculosis admitted during the same period were selected as non-infected group, and the levels of NLR, FAR, and RDW in peripheral blood of the patients of the two groups were collected for determination, and NLR, FAR and RDW levels of the patients of the two groups were compared.The receiver operating characteristic (ROC) curve was used to assess the performance of the above indicators for early diagnosis of PTB combined with bacterial infection. Results: The levels of NLR, FAR and RDW were significantly higher in the infected group compared with the non-infected group, and the differences were statistically significant (P < 0.05).The levels of NLR were positively correlated with the levels of leukocytes, C-reactive protein and D-dimer.ROC curve analysis showed that the area under the curve (AUC) for the diagnosis of pulmonary tuberculosis combined with bacterial infection by blood NLR, FAR and RDW were 0.861, 0.818, 0.799; the AUC value after the combination of the three was 0.982. The validation results showed that the diagnostic sensitivity (98.6%) and specificity (89.58%) of NLR and FAR combined with RDW were higher than those of NLR, FAR and RDW alone. Conclusion: Combined detection of blood NLR, FAR and RDW levels has high clinical diagnostic value for diagnosing pulmonary tuberculosis combined with bacterial infection.

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The fibrinogen-albumin ratio as a novel prognostic factor for elderly patients with osteosarcoma

Cited by 2 publications

References 39 publications

Prognostic and clinicopathological significance of fibrinogen-to-albumin ratio (FAR) in patients with breast cancer: a meta-analysis

Prognostic and clinicopathological significance of fibrinogen-to-albumin ratio (FAR) in patients with breast cancer: a meta-analysis

Diagnostic value of neutrophil-to-lymphocyte ratio, fibrinogen-to-albumin ratio and red blood cell distribution width in tuberculosis combined with bacterial infection

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