This chapter explores the transformative potential of precision medicine and AI in revolutionizing healthcare delivery. By tailoring treatments to individual patient profiles through genomic insights and advanced analytics, personalized healthcare optimizes therapeutic efficacy, particularly in oncology, rare diseases, and chronic conditions. Case studies illustrate the economic advantages of targeted interventions, highlighting cost efficiency through reduced trial-and-error treatments and improved patient outcomes. However, the integration of AI introduces ethical dilemmas, including data privacy concerns, algorithmic biases, and the implications of genetic editing technologies. Global examples of healthcare systems implementing AI-driven personalized medicine provide valuable insights into best practices and lessons learned from early adopters. As the landscape of healthcare evolves, the chapter emphasizes the need for interdisciplinary collaboration, robust data infrastructure, and active patient engagement to navigate the complexities of precision medicine.