The Finnish Allergy Programme 2008–2018 works

Haahtela, Tari; Valovirta, Erkka; Bousquet, Jean; Mäkelä, Mika J.

doi:10.1183/13993003.00470-2017

Cited by 61 publications

(89 citation statements)

References 20 publications

(16 reference statements)

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“…This study also suggests that, in real life, there is a phenotype of severe AR that needs to be considered in terms of public health and cost savings, as the severe form causes disability. This phenotype is in focus with the Finnish Allergy Program …”

Section: Discussionmentioning

confidence: 99%

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study

Bousquet

Arnavielhe²,

Bedbrook³

et al. 2017

Allergy

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Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Users with a score of 3 or 4 had a significant impairment in quality-of-life questionnaires.

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Section: Discussionmentioning

confidence: 99%

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study

Bousquet

Arnavielhe²,

Bedbrook³

et al. 2017

Allergy

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“…11 Also, Finnish allergy program may have encouraged parents to enroll symptomatic children to nature-oriented daycares. 12 However, as the skin microbiota correlated with daycare type, and its systemic importance has been proposed, 13 we suggest that longitudinal studies with larger cohorts should address the potential of daycare environment and practice in supporting balanced immune development and health.…”

Section: Nature-oriented Daycare Diversifies Skin Microbiota In Childmentioning

confidence: 91%

Nature‐oriented daycare diversifies skin microbiota in children—No robust association with allergies

Lehtimäki

Laatikainen

Karkman

et al. 2018

Pediatric Allergy Immunology

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“…Immunotherapy was also promoted . The mid‐term results indicate that the programme works as burden of allergy and asthma has started to decrease, for example, in terms of allergy diets, asthma emergencies and overall costs …”

Section: Can We Change the Course?mentioning

confidence: 99%

A biodiversity hypothesis

Haahtela

2019

Allergy

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288

164

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Biodiversity hypothesis states that contact with natural environments enriches the human microbiome, promotes immune balance and protects from allergy and inflammatory disorders. We are protected by two nested layers of biodiversity, microbiota of the outer layer (soil, natural waters, plants, animals) and inner layer (gut, skin, airways). The latter inhabits our body and is colonized from the outer layer. Explosion of human populations along with cultural evolution is profoundly changing our environment and lifestyle. Adaptive immunoregulatory circuits and dynamic homeostasis are at stake in the newly emerged urban surroundings. In allergy, and chronic inflammatory disorders in general, exploring the determinants of immunotolerance is the key for prevention and more effective treatment. Loss of immunoprotective factors, derived from nature, is a new kind of health risk poorly acknowledged until recently.The paradigm change has been implemented in the Finnish allergy programme (2008-2018), which emphasized tolerance instead of avoidance. The first results are promising, as allergy burden has started to reduce. The rapidly urbanizing world is facing serious biodiversity loss with global warming, which are interconnected.Biodiversity hypothesis of health and disease has societal impact, for example, on city planning, food and energy production and nature conservation. It has also a message for individuals for health and well-being: take nature close, to touch, eat, breathe, experience and enjoy. Biodiverse natural environments are dependent on planetary health, which should be a priority also among health professionals. K E Y W O R D Sasthma, biodiversity, hygiene hypothesis, immune tolerance, microbiome

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The Finnish Allergy Programme 2008–2018 works

Abstract: @ERSpublicationsRevisiting the asthma and allergy paradigms has led to actions relevant to society and healthcare as a whole http://ow.ly/MBG530bPvd6Cite this article as: Haahtela T, Valovirta E, Bousquet J, Mäkelä M, et al.

Cited by 61 publications

References 20 publications

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study

Nature‐oriented daycare diversifies skin microbiota in children—No robust association with allergies

A biodiversity hypothesis

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