The First Case in Japan of Fulminant Myocarditis Due to Multisystem Inflammatory Syndrome in Children (MIS-C) That Required Mechanical Circulatory Support

Nishikubo, Takumi; Tsujii, Nobuyuki; Kajimoto, Takahiro; Ohara, Ayaka; Asai, Yuji; Ueda, Tomoya; Takeda, Maiko; Tanaka, Koushi; Fukushima, Hidetada; Watanabe, Makoto; Nogami, Keiji

doi:10.1536/ihj.23-116

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The prevalence of MIS-C is lower in Asian countries including Japan compared with that in the United States and Europe, although the prevalence of KD is much higher in Japan. 10 These findings indicate that this discrepancy might be caused by the racial differences in immune responses for SARS-CoV2 infection. Furthermore, the small sample size in this study might be a cause of this discrepancy.…”

Section: Discussionmentioning

confidence: 97%

Clinical Usefulness of T-Cell Receptor Vβ Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock Syndrome and Kawasaki Disease

Kaneko,

Noguchi,

Hatano

et al. 2023

Pediatric Infectious Disease Journal

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The specific expansion of T-cell receptor β chain variable region (TCR-Vβ21.3+) CD4+ and CD8+ T cells was observed in Japanese patients with multisystem inflammatory syndrome in children. In contrast, these findings were not observed in patients with toxic shock syndrome and Kawasaki disease. T-cell receptor β chain variable region repertoire analysis to detect specific expansion of Vβ21.3+ T cells might be useful for differentiating multisystem inflammatory syndrome in children from toxic shock syndrome and Kawasaki disease.

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Section: Discussionmentioning

confidence: 97%

Clinical Usefulness of T-Cell Receptor Vβ Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock Syndrome and Kawasaki Disease

Kaneko,

Noguchi,

Hatano

et al. 2023

Pediatric Infectious Disease Journal

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show abstract

“…Surprisingly, large MIS‐C cohort studies from China, Japan, the Philippines, Thailand, Malaysia, and others were not identified. Extreme cases reported from Japan have shown the need for extracorporeal membrane oxygenation and continuous hemodiafiltration for MIS‐C‐related acute myocardial and renal injury and the potential benefit of infliximab in a patient with refractory MIS‐C 47–50 …”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations and outcomes associated with PICU admission in children with multisystem inflammatory syndrome in Taiwan: A retrospective cohort study

Tseng,

Lin,

Huang

et al. 2023

Int J of Rheum Dis

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BackgroundMultisystem inflammatory syndrome in children (MIS‐C) is a rare and serious systemic inflammatory disorder that occurs following a severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. This study aims to investigate the clinical manifestations, risk factors associated with pediatric intensive care unit (PICU) admission, and outcome among children with MIS‐C in Taiwan.MethodsA retrospective analysis was conducted among pediatric patients diagnosed with MIS‐C between June 2022 and February 2023 at Chang Gung Memorial Hospital, Linkou, Taiwan. Data on demographics, clinical features, laboratory findings, treatment modalities, and outcomes were collected and analyzed.ResultsTwenty‐eight MIS‐C patients, including 9 boys and 19 girls, with an average age of 5.3 ± 3.8 years old, were enrolled. Most of the cases (78.6%) were diagnosed following the first pandemic wave of COVID‐19 in Taiwan. The leading clinical manifestations observed were fever (100%), skin rash (64.3%), tachycardia (46.4%), and vomiting (46.4%). Nine patients (32.1%) were admitted to the PICU due to hypotension or neurological manifestations. Higher levels of band‐form white blood cells, procalcitonin, ferritin, d‐dimer, prothrombin time, NT‐proBNP, and lower platelet levels on arrival were associated with PICU admission (p = 3.9 × 10−2,9 × 10−3, 4 × 10−3,1 × 10−3, 5 × 10−3, 4.1 × 10−2, and 3.4 × 10−2, respectively). Arrhythmia in one case (3.5%) and coronary artery abnormalities, including dilatation in two cases (7.1%) and small aneurysms in one case (3.5%) were identified. Regardless of ICU admission, no patients experienced systolic dysfunction or mortality following treatment.ConclusionMIS‐C cases in Taiwan have a favorable outcome. Although one‐third of the patients required PICU admission, none of the MIS‐C cases resulted in severe cardiovascular morbidity or mortality. This study provides valuable insights into the clinical manifestations and outcomes associated with PICU admission in children with MIS‐C in Taiwan.

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Evolution of Cardiovascular Findings in Multisystem Inflammatory Syndrome in Children (MIS-C) Across COVID-19 Variants: Common Trends and Unusual Presentations

Khan,

Ordog,

Hong

et al. 2024

Pediatr Cardiol

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The First Case in Japan of Fulminant Myocarditis Due to Multisystem Inflammatory Syndrome in Children (MIS-C) That Required Mechanical Circulatory Support

Cited by 3 publications

References 13 publications

Clinical Usefulness of T-Cell Receptor Vβ Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock Syndrome and Kawasaki Disease

Clinical Usefulness of T-Cell Receptor Vβ Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock Syndrome and Kawasaki Disease

Clinical manifestations and outcomes associated with PICU admission in children with multisystem inflammatory syndrome in Taiwan: A retrospective cohort study

Evolution of Cardiovascular Findings in Multisystem Inflammatory Syndrome in Children (MIS-C) Across COVID-19 Variants: Common Trends and Unusual Presentations

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