The First Electropysiological Abnormality In New-onset DM: Autonomic Tests

memiş, zülfikar; çevik, nihat; Acar, Hürtan; Günaydın, Sefer; Çokar, Ayşe Özlem

doi:10.29399/npa.27952

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sympathetic skin response (SSR) measures electrodermal activity evoked by sympathetic stimulation such as electrical stimulation [ 26 ]. It has been shown recently that SSR may be used as an indicator for diabetic cardiac autonomic neuropathy [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients

et al. 2023

View full text Add to dashboard Cite

Background and Objectives: Diagnostic ultrasound of the vagus nerve has been used to examine different polyneuropathies, and it has been suggested to be useful as a marker of autonomic dysfunction in diabetic patients. Materials and Methods: We analyzed the cross-sectional area (CSA) of the right vagus nerve of 111 patients with type 2 diabetes in comparison to 104 healthy adults and 41 patients with CIDP (chronic inflammatory demyelinating polyneuropathy). In the diabetes group, sympathetic skin response (SSR) was measured as an indicator for autonomic neuropathy. Carotid intima–media thickness (CIMT) was measured as a surrogate for atherosclerosis. Clinical symptoms of polyneuropathy were assessed using the Neuropathy Symptom Score and the Neuropathy Disability Score. Results: In total, 61.3% of the diabetes patients had clinical signs of polyneuropathy; 23.4% had no SSR at the feet as an indicator of autonomic neuropathy. Mean vagus nerve CSA did not differ in patients with and without diabetic polyneuropathy or in diabetic patients with and without SSR at the feet. No significant correlation was found between vagus nerve CSA and CIMT or SSR parameters in diabetic patients. Mean CSA of the right vagus nerve was slightly larger in diabetic patients (p = 0.028) and in patients with CIDP (p = 0.015) than in healthy controls. Conclusions: Effect sizes and mean differences were rather small so that a reliable diagnosis cannot be performed based on the vagus nerve measurement of a single person alone. Vagus nerve CSA seems not suitable as an indicator of autonomic dysfunction or cardiovascular risk in diabetic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients

et al. 2023

View full text Add to dashboard Cite

show abstract

Electrodermal activity and its molecular mechanisms: Unraveling insights into skin diseases

Zhu,

Song,

Liu

et al. 2024

TIL

View full text Add to dashboard Cite

<p>Electrodermal activity (EDA) refers to the changes in electrical potential recorded on the skin surface, which mainly reflect the electrical properties of the skin and sympathetic nerve activity reflected by sweat secretion. Various dermatoses impair the skin barrier and alter the function of innervated nerves, resulting in significant fluctuations in EDA. This manuscript aims to provide a comprehensive overview of the molecular mechanisms underlying representative skin symptoms related to inflammation, fibrosis, and sweat gland disorders, and to explore the correlation of these mechanisms with EDA components. The physiological significance of EDA is discussed to provide a new perspective for the clinical application of EDA.</p>

show abstract

The First Electropysiological Abnormality In New-onset DM: Autonomic Tests

Cited by 2 publications

References 8 publications

Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients

Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients

Electrodermal activity and its molecular mechanisms: Unraveling insights into skin diseases

Contact Info

Product

Resources

About