The First Human Blood, ---/---, which Lacks the ‘D-like’ Antigen

Levine, Philip; Celano, Marino; Vos, G. H.; Morrison, Jamie C.

doi:10.1038/194304a0

Cited by 38 publications

(4 citation statements)

References 4 publications

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“…The laboratory findings in this study of the Rh,,,, propositus closely agree with the example reported by V0s17 which was further studied by Levine,7 and that of Levinego 10 and Haber.4 All have shown an absence of any expression of the Rh-Hr antigens; all lack the Landsteiner-Wiener (LW) or "D-like" antigen, and all react weakly or not at all with anti-U serum. 13 This case, as well as those of Levine and Haber, shows evidence of shortened erythrocyte survival times.l.14 The family is similar to that of Levine's Rh,,,, individual in that both had a significant number of individuals in the family with weakened reactions to anti-D sera, and all were of the phenotypes R, or R,R1.…”

Section: Discussionsupporting

confidence: 89%

Another Example of Phenotype Rh_null

et al. 1970

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Blooddonor typing provided the sixth example of a person with the rare phenotype, Rh..,,. Serologic investigation of the propositus and his family gives indirect support for the theory that the homozygous state of amorphic genes ( X o r / X o r ) at a locus independent of Rh can block the production of the precursor substance upon which the R h genes act to form the Rh antigenic determinants on red blood cells.

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Section: Discussionsupporting

confidence: 89%

Another Example of Phenotype Rh_null

et al. 1970

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“…The random two-dimensional distribution of the Rho(D) antigen as observed in our experiments may therefore represent an instantaneously fixed arrangement of a component which normally is continuously diffusible in the plane of the erythrocyte membrane. Such a structurally passive role for the Rho(D) antigen in the membrane must be reconciled, however, with the observations that those rare individuals who lack all known Rh-Hr antigenic determinants on their erythrocytes (29,30) often appear to have an unexplained hemolytic anemia (31).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Two-Dimensional Ultrastructural Distribution of Rh _o (D) Antigenic Sites on Human Erythrocyte Membranes ^*

Nicolson

Masouredis

Singer

1971

Proc. Natl. Acad. Sci. U.S.A.

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A method is described for determining the two-dimensional distribution of specific antigens on cell surfaces, and is applied to the D antigen of the Rh antigenic system. Rh-positive human erythrocytes are allowed to react with purified 1251-labeled human anti-Rh0(D) -yglobulin antibodies, and the sensitized cells are then lysed at an air-water interface. The residual cell membranes are spread flat by surface forces, and are picked up on a carbon-strengthened collodion-coated electron microscope grid. The membranes are then stained with ferritinconjugated goat -antibodies directed against human -yglobulins. Only Rh-positive cells sensitized with antiRho(D) antibodies bind the ferritin-conjugated antihuman -y-globulins. The

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“…This was the first example of the rare phenotype now termed Rhnun, after the suggestion of Ceppellini [7]. As well as Rh antigens, the cells were found to lack the phenotypically related, but genetically independent, LW antigen [6]. Since the propositus had no living parents, sibs or offspring, it was considered that no information on the genetic basis for her phenotype was obtainable.…”

Section: Introductionmentioning

confidence: 99%

Rh Blood Groups of Australian Aborigines in the Tribe Containing the Original Rh(null) Propositus

Boettcher¹,

Hasekura²

1971

Vox Sanguinis

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Quantitative haemagglutination studies on samples from 113 members of the tribe revealed 5 individuals whose red cells showed weak expression of Rh antigens. Two were of group R(1) R(2), 2 of group R(1) R(z), and one of group R(2)R(0). All were close tribal relatives of the propositus. It is proposed that these individuals are heterozygous for the allele for which the propositus is homozygous, and which is responsible for her Rh(null) phenotype. The case appears to be similar to that studied by Levine and co-workers, and it seems that the propositus does not express Rh antigens due to a genetically-determined lack of a precursor, which is necessary for Rh (and UW) antigen biosynthesis. The locus at which the block has occurred is not closely linked with the Rh locus.

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The First Human Blood, ---/---, which Lacks the ‘D-like’ Antigen

Cited by 38 publications

References 4 publications

Another Example of Phenotype Rh_null

Another Example of Phenotype Rh_null

Quantitative Two-Dimensional Ultrastructural Distribution of Rh _o (D) Antigenic Sites on Human Erythrocyte Membranes ^*

Rh Blood Groups of Australian Aborigines in the Tribe Containing the Original Rh(null) Propositus

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The First Human Blood, ---/---, which Lacks the ‘D-like’ Antigen

Cited by 38 publications

References 4 publications

Another Example of Phenotype Rhnull

Another Example of Phenotype Rhnull

Quantitative Two-Dimensional Ultrastructural Distribution of Rh o (D) Antigenic Sites on Human Erythrocyte Membranes *

Rh Blood Groups of Australian Aborigines in the Tribe Containing the Original Rh(null) Propositus

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Another Example of Phenotype Rh_null

Another Example of Phenotype Rh_null

Quantitative Two-Dimensional Ultrastructural Distribution of Rh _o (D) Antigenic Sites on Human Erythrocyte Membranes ^*