The first reported case of a variant of Mal de Maleda of the Gamborg-Nielsen type in an Egyptian origin patient

Abstract

How to cite this article: Al-Husain KM, Al-Thubaiti AA, Alzahrani FM, Bukhari IA, El-Shawarby M. The fi rst reported case of a variant of Mal de Maleda of the Gamborg-Nielsen type in an Egyptian origin patient. ABSTRACTMal de Meleda is a rare genodermatosis with an autosomal recessive inheritance. Mutations in the SLURP1 gene are the cause of this disease. Clinically, it is characterized by progressive palmoplantar hyperkeratosis exhibiting a transgradiens pattern extending to the dorsal aspects of the hands and feet in a glove and stocking pattern. It is also associated with hyperhidrosis, nail changes, subungual hyperkeratosis and perioral erythema. Here we report the first case of Gamborg-Nielsen variant of Mal de Meleda disorder in a patient of an Egyptian origin.