The First Specific Antibody against Cytotoxic Polyacetylenic Alcohol, Panaxynol.

Saita, Tetsuya; Matsunaga, Hisashi; Yamamoto, Hiroshi; Fujito, Hiroshi; Mori, Masato

doi:10.1248/cpb.41.549

Cited by 19 publications

(18 citation statements)

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“…The cytotoxic activity of C 17 -polyacetylenes 26 and 28 against leukemia cells (L-1210) was about 20 times higher than that of the C 14 -polyacetylene (27). Panaxydol (5), heptadeca-1,8-diene-4,6-diyne-3,10-diol (20), and 8-methoxy-panaxydol (29) from Acanthopanax senticosus roots seemed to induce various pro-apoptosis mechanisms in animal cells (55)(56)(57)(58)(59)(60)(61)(62). Compound 29 was preferably used in treating leukemia.…”

Section: Acetylenic Metabolites From Plant Speciesmentioning

confidence: 98%

“…Thus, panaxydol (5), panaxynol (falcarinol) (6), and panaxytriol (7) are present in red ginseng powder at concentrations of 297, 250, and 320 µg/g, respectively. The antitumor alcohols panaxydol and panaxynol, isolated from a powder of the root of P. ginseng, inhibited the growth of various kinds of cultured tumor cell lines (28)(29)(30)(31)(32).…”

Section: Acetylenic Metabolites From Plant Speciesmentioning

confidence: 99%

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Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

129

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This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities only for more than 300 acetylenic lipids and their derivatives isolated from living organisms.

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Section: Acetylenic Metabolites From Plant Speciesmentioning

confidence: 98%

Section: Acetylenic Metabolites From Plant Speciesmentioning

confidence: 99%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

129

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“…A polyacetylenic alcohol of ginseng, panaxynol, has been shown to inhibit the growth of various kinds of cultured tumor cells in a dose-dependent manner. The tumor cell rapidly consumed the compound (Saita et al 1993).…”

Section: Panax Ginseng Ca Mey (Root)mentioning

confidence: 99%

Phytochemicals and Antioxidants

Lin¹

1994

Functional Foods

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“…Some of these compounds occur in minor concentrations in food plants but have so far not been considered to be responsible for the health‐promoting effects of fruits and vegetables 13. An example is bioactive polyacetylenes (falcarinol and falcarindiol), which have been found in carrots and other vegetables of the Apiaceae family and in several traditional oriental herbs such as ginseng root ( Panax ginseng CA Meyer)14, 15 and Dendropanax arboreus (L) Descaine et Planchon16 of the Araliaceae family.…”

Section: Introductionmentioning

confidence: 99%

“…Falcarinol ((9Z)‐heptadeca‐1,9‐dien‐4,6‐diyn‐3‐ol), synonymous with ‘panaxynol’ (Fig 1), is the most bioactive of the carrot polyacetylenes 13–15, 17. Falcarinol has been shown to have a pronounced cytotoxic activity against several human tumour cell lines in vitro ,15–17 and preliminary in vivo evaluation of the cytotoxic activity of falcarinol has also demonstrated its potential for in vivo antitumour activity 16. The antimutagenic properties of ginseng root,15, 17 for example, and its stimulatory effect on the immune system during bacterial infection18 may be due to falcarinol and related polyacetylenes.…”

Section: Introductionmentioning

confidence: 99%

Numerical study on peristaltic flow of generalized burgers' fluids in uniform tubes in the presence of an endoscope

Tripathi

2011

Numer Methods Biomed Eng

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SUMMARYThis manuscript focuses on the numerical study of peristaltic flow of generalized Burgers' fluid through the gap between concentric uniform tubes (inner tube is rigid and outer tube is flexible) with an endoscope. The analysis has been carried out under the long wavelength and low Reynolds number approximations. The expressions of axial velocity, volume flow rate, pressure gradient and stream function are obtained by two different methods, namely; the homotopy perturbation method and the variational iteration method. The details of implementation of two methods are provided. Parametric study is performed at the end of the paper for analyzing the effects of emerging parameters on pressure-rise per wavelength friction forces at the walls and trapping. It is found that pressure-rise diminishes with increase in the magnitude of the first fractional parameter, second material constant and the ratio of radii of tubes, whereas the effect of second fractional parameter and other three material constants (first, third and fourth) on pressure-rise is found to be the opposite. The influences of all these parameters on friction force (on the inner and outer tubes) are opposite to that of pressure-rise.

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The First Specific Antibody against Cytotoxic Polyacetylenic Alcohol, Panaxynol.

Cited by 19 publications

References 0 publications

Anticancer activity of natural and synthetic acetylenic lipids

Anticancer activity of natural and synthetic acetylenic lipids

Phytochemicals and Antioxidants

Numerical study on peristaltic flow of generalized burgers' fluids in uniform tubes in the presence of an endoscope

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