The First Successful Lower Extremity Transplantation: 6-Year Follow-Up and Implications for Cortical Plasticity

Abstract

Vascularized composite allotransplantation as a viable reconstructive option is gaining recognition and new cases are being reported with increasing frequency including hand, face and laryngeal transplantation. However, only one successful complete lower limb transplantation has been reported to date, in which a functioning limb from one ischiopagus twin with a lethal cardiac anomaly was transplanted to the other. Six years later, the patient is mobilizing well and engaging in sporting activities with her peers in a mainstream school. Clinical evaluation of motor and sensory modalities demonstrated a good functional result. Quality of life was assessed using the short form-36 health survey and lower extremity functional scale disclosing a high level of social and physical capacity. Functional magnetic resonance imaging was performed and showed cortical integration of the limb; the implications of cortical plasticity and vascularized composite allotransplantation for the correction of congenital limb anomalies are presented.Key words: Conjoined twins, cortical plasticity, fMRI, lower extremity, vascularized composite allotransplantation Abbreviations: AFNI, analysis of functional neuroimages; BOLD, blood oxygen level dependent; FA, fractional anisotropy; fMRI, functional magnetic resonance imaging; FOV, field of view; FWHM, full width at half maximum; LEFS, lower extremity functional scale; MA,

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