The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3

Lagan, Paula; Devaney, Ryan; Smyth, Victoria

doi:10.3390/v13020235

Cited by 11 publications

(7 citation statements)

References 95 publications

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“…Since metagenomic analyses produce vast amount of data, scrutiny of all available clinical, diagnostic and epidemiological results is required for accurate evaluation of the respective case. Metagenomic analyses are currently also very popular in epidemiological investigations of various health issues and frequently result in finding novel species [239,242].…”

Section: Molecular Diagnosticsmentioning

confidence: 99%

Diagnosing Infectious Diseases in Poultry Requires a Holistic Approach: A Review

Liebhart

Bilić

Grafl

et al. 2023

Poultry

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Controlling infectious diseases is vital for poultry health and diagnostic methods are an indispensable feature to resolve disease etiologies and the impact of infectious agents on the host. Although the basic principles of disease diagnostics have not changed, the spectrum of poultry diseases constantly expanded, with the identification of new pathogens and improved knowledge on epidemiology and disease pathogenesis. In parallel, new technologies have been devised to identify and characterize infectious agents, but classical methods remain crucial, especially the isolation of pathogens and their further characterization in functional assays and studies. This review aims to highlight certain aspects of diagnosing infectious poultry pathogens, from the farm via the diagnostic laboratory and back, in order to close the circle. By this, the current knowledge will be summarized and future developments will be discussed in the context of applied state-of-the-art techniques. Overall, a common challenge is the increasing demand for infrastructure, skills and expertise. Divided into separate chapters, reflecting different disciplines, daily work implies the need to closely link technologies and human expertise in order to improve bird health, the production economy and to implement future intervention strategies for disease prevention.

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Section: Molecular Diagnosticsmentioning

confidence: 99%

Diagnosing Infectious Diseases in Poultry Requires a Holistic Approach: A Review

Liebhart

Bilić

Grafl

et al. 2023

Poultry

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“…Molecular Genetics Evolutionary Analysis version 11 was used for phylogenetic tree reconstruction using the neighbor-joining algorithm with 1000 bootstrap replicates. These included sequences of different genotypes of CAstV and ANV according to ORF2 analysis described by references [ 20 , 21 , 22 ]. The tree was drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree.…”

Section: Figurementioning

confidence: 99%

Detection and Molecular Characterization of Enteric Viruses in Poultry Flocks in Hebei Province, China

Chen

Wang

et al. 2022

Animals

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Enteric viruses, as a potential pathogen, have been found to be vital causes of economic losses in poultry industry worldwide. The enteric viruses widely studied to date mainly include avian nephritis virus (ANV), avian reovirus (ARe), chicken astrovirus (CAstV), chicken parvovirus (ChPV), fowl adenovirus group I (FAdV-1), infectious bronchitis virus (IBV), and avian rotavirus (ARoV). This paper aimed to identify single and multiple infections of the seven enteric viruses using the data obtained from positive 145 enteric virus samples in poultry flocks from different areas in Hebei Province, throughout the period from 2019 to 2021. Next, the correlation between bird age and clinical signs was investigated using PCR and RT-PCR techniques. Furthermore, the whole genomes of seven parvovirus strains and open reading frame 2 (ORF2) of six CAstV strains and eight ANV strains were sequenced for phylogenetic analysis and recombination analysis, to characterize the viruses and evaluate species correlation and geographic patterns. A total of 11 profiles of virus combinations were detected; 191 viruses were detected in 145 samples; 106 single infections were reported in 73.1% of the samples; and multiple infections were detected in the remaining 26.9%. For viruses, 69% of ChPV was correlated with single infection, while ANV (61.4%) and CAstV (56.1%) were correlated with multiple infections. However, IBV and ARe were not detected in any of the samples. Recombination events were reported in parvovirus, and all CAstV sequences investigated in this paper were included within genotype Bii. The eight ANV strains pertained to different subtypes with significant differences. The above results revealed for the first time the complexity of enteric viruses over the past several years, thus contributing to disease prevention and control in the future.

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“…Additionally, TAstV-2 has been detected in apparently healthy flocks of turkeys [50,51]. The ANV is associated with nephritis and RSS in chicken and turkey flocks and other avian species [52].…”

Section: Astrovirusmentioning

confidence: 99%

Poult Enteritis and Mortality Syndrome in Turkey Poults: Causes, Diagnosis and Preventive Measures

Shehata

Basiouni

Sting

et al. 2021

Animals

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Poult enteritis and mortality syndrome (PEMS) is one of the most significant problem affecting turkeys and continues to cause severe economic losses worldwide. Although the specific causes of PEMS remains unknown, this syndrome might involve an interaction between several causative agents such as enteropathogenic viruses (coronaviruses, rotavirus, astroviruses and adenoviruses) and bacteria and protozoa. Non-infectious causes such as feed and management are also interconnected factors. However, it is difficult to determine the specific cause of enteric disorders under field conditions. Additionally, similarities of clinical signs and lesions hamper the accurate diagnosis. The purpose of the present review is to discuss in detail the main viral possible causative agents of PEMS and challenges in diagnosis and control.

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The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3

Cited by 11 publications

References 95 publications

Diagnosing Infectious Diseases in Poultry Requires a Holistic Approach: A Review

Diagnosing Infectious Diseases in Poultry Requires a Holistic Approach: A Review

Detection and Molecular Characterization of Enteric Viruses in Poultry Flocks in Hebei Province, China

Poult Enteritis and Mortality Syndrome in Turkey Poults: Causes, Diagnosis and Preventive Measures

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