The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion

Kuo, Hsi-Kung; Kuo, Ming‐Tse; Chen, Yung-Jen; Wu, Pei-Chang; Chen, Chih-Hsin; Chen, Yi-Hao

doi:10.1007/s00417-009-1205-4

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…The latency of the 30-Hz flicker in ffERG is reported to be useful in predicting the occurrence of new vessels in CRVO. 13,14,34,35 In our patients, we encountered five eyes with ischemic CRVO that showed no new vessels on fluorescein angiography. These eyes had lower amplitudes, particularly in PhNR, which represents inner retinal dysfunction.…”

Section: Discussionmentioning

confidence: 98%

Focal Macular Electroretinogram in Macular Edema Secondary to Central Retinal Vein Occlusion

Ogino¹,

Tsujikawa²,

Nakamura³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 98%

Focal Macular Electroretinogram in Macular Edema Secondary to Central Retinal Vein Occlusion

Ogino¹,

Tsujikawa²,

Nakamura³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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“…Clinical Findings and Ancillary Studies, below). It was also reported that interocular amplitude difference of 23 µV and interocular amplitude ratio of 60% on 30 Hz flicker ERG could be also used as cut-off points to differentiate between iCRVO and non-iCRVO (161) (see section VI. Clinical…”

Section: Accepted Manuscript 10mentioning

confidence: 99%

Ischemic retinal vein occlusion: characterizing the more severe spectrum of retinal vein occlusion

Khayat

Williams

Lois

2018

Survey of Ophthalmology

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Retinal vein occlusion (RVO)-including central RVO, branch RVO, and hemicentral and hemispheric RVO-is the second most common vascular cause of visual loss, surpassed only by diabetic retinopathy. The presence and extent of retinal ischemia in RVO is associated with a worse prognosis. On this basis, most previously conducted studies considered ischemic retinal vein occlusion (iRVO) and non-iRVO as separate entities based on set thresholds of existing retinal ischemia as determined by fundus fluorescein angiography. Other diagnostic technologies have been used specifically in the differentiation of ischemic central retinal vein occlusion and nonischemic central retinal vein occlusion. To date, there is no fully accepted definition for iRVO. Some clinicians and researchers may favor establishing a clear differentiation between these forms of RVO; others may prefer not to consider iRVO as a separate entity. Whatever the case, retinal ischemia in RVO confers a higher risk of visual loss and neovascular complications; thus, it should be determined as accurately as possible in patients with this disease and be considered in clinical and experimental studies. Most recently conducted clinical trials evaluating new treatments for macular edema secondary to RVO included none or only few patients with iRVO based on previous definitions (i.e., few patients with sizeable areas of retinal ischemia were recruited in these trials), and thus it is unclear whether the results observed in recruited patients could be extrapolated to those with retinal ischemia. There has been scant research aiming at developing and/or testing treatments for retinal ischemia, as well as to prevent new vessel formation as a result of RVO. We provide a detailed review of the knowledge gathered over the years on iRVO, from controversies on its definition and diagnosis to the understanding of its epidemiology, risk factors and pathogenesis, the structural and functional effects of this disease in the eye and its complications, natural history, and outcomes after treatment. In each section, the definition of iRVO used is given so, independently of whether iRVO is considered a separate clinical entity or a more severe end of the spectrum of RVO, the information will be useful to clinicians to determine patient's risk, guide therapeutic decisions, and counsel patients and for researchers to design future studies.

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“…Another useful investigation to differentiate ischemic and non-ischemic CRVO is a flicker ERG (electroretinogram) [43].…”

Section: Symptoms and Clinical Signsmentioning

confidence: 99%

Retinal vein thrombosis: pathogenesis and management

Rehák

Wiedemann

2010

Journal of Thrombosis and Haemostasis

208

157

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To cite this article: Rehak M, Wiedemann P. Retinal vein thrombosis: pathogenesis and management. J Thromb Haemost 2010; 8: 1886-94.Summary. Retinal vein occlusion (RVO) is the most common retinal vascular disease after diabetic retinopathy. Owing to its multifactorial nature, however, management of this condition remains a challenge. Of the two main types of RVO, branch retinal vein occlusion (BRVO) is more prevalent than central retinal vein occlusion (CRVO). Most patients develop the disease at an elderly age, and more than half of them have associated systemic disorders (e.g. hypertension, hyperlipidemia and/or diabetes mellitus). There is no evidence to suggest routine testing for heritable thrombophilias in patients with RVO. The main cause of the visual impairment is macular edema, while neovascularization of the retina and optic disc are the most serious complications leading to vitreous hemorrhage, retinal detachment and neovascular glaucoma. Macular grid laser photocoagulation is an effective treatment for macular edema in patients with BRVO and a visual acuity of 20/40 or less. Other treatment options for reducing the edema are intravitreal steroids, anti-VEGF drugs and vitrectomy. The recently introduced intravitreal application of steroids and anti-VEGF drugs may prove to be a better approach for improving visual acuity. Finally, scatter panretinal laserphotocoagulation can effectively treat neovascularization and its secondary complications.

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The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion

Abstract: Interocular comparison of amplitude is a good solution for avoiding the variability of ERG. An interocular amplitude ratio of flicker ERG of 60% is a succinct, useful parameter in clinical practices for differentiating ischemic from nonischemic CRVO.

Cited by 7 publications

References 24 publications

Focal Macular Electroretinogram in Macular Edema Secondary to Central Retinal Vein Occlusion

Focal Macular Electroretinogram in Macular Edema Secondary to Central Retinal Vein Occlusion

Ischemic retinal vein occlusion: characterizing the more severe spectrum of retinal vein occlusion

Retinal vein thrombosis: pathogenesis and management

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