The flinders sensitive line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat

Dilsaver, Steven C.; Peck, Jason A.; Overstreet, David H.

doi:10.1016/0091-3057(92)90053-i

Cited by 14 publications

(7 citation statements)

References 21 publications

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“…Subsequently, the chronic blockade of the AChE with specific inhibitors selectively impaired glutamatergic functions and excitatory synaptic structures independently [55]. In contrast, other studies have shown that AChE inhibitors increase the depressive phenotype [56]. In our study, we observed a 50% decrease in AChE activity in the brain tissues of depressed rats, while we observed a 25% increase in AChE activities in the treatment groups due to increasing doses.…”

Section: Discussioncontrasting

confidence: 50%

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

Yeni

Çakır

Hacımüftüoğlu

et al. 2022

JPM

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Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as the main immune system histamine receptor with a pro-inflammatory role. To understand the role of this receptor, the drug JNJ7777120 was used to reveal the chronic depression-glutamate relationship. We have important findings showing that the H4 antagonist increases the glutamate transporters’ instantaneous activity. In our experiment, it has been shown that blocking the H4 receptor leads to increased neuron cell viability and improvement in behavioral ability due to glutamate. Therefore, JNJ can be used to prevent neurotoxicity, inhibit membrane phospholipase activation and free radical formation, and minimize membrane disruption. In line with our findings, results have been obtained that indicate that JNJ will contribute to the effective prevention and treatment of depression.

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Section: Discussioncontrasting

confidence: 50%

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

Yeni

Çakır

Hacımüftüoğlu

et al. 2022

JPM

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“…Nicotinic binding patterns in a variety of subcortical regions including the hippocampus haves been found to significantly vary in different mouse strains (Marks et al 1989a). Strain differences in nicotine sensitivity has been seen for a variety of neurobehavioral responses such as thermoregulation, seizure sensitivity and locomotor activity (Marks et al 1989b;Miner and Collins 1989;Dilsaver et al 1991). Critical to the current discussion, differential effects of nicotine on memory function have been seen in various strains of rats or mice.…”

Section: Nicotine Effects In Experimental Animalsmentioning

confidence: 95%

Nicotinic systems and cognitive function

1992

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Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.

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“…A selectively bred line of rats with increased sensitivity to acetylcholinesterase, the Flinders Sensitive Line, exhibit an exaggerated behavioral and physiological response to cholinergic agents such as nicotine (Dilsaver et al, 1992). Furthermore, this line exhibits depression-like behaviors including lower startle thresholds (Markou et al, 1994), fulfilling some criteria of face, construct, and predictive validities [see (Overstreet, 1993) for review].…”

Section: The Original Adrenergic-cholinergic Balance Hypothesis Ofmentioning

confidence: 99%

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

Enkhuizen

Janowsky

Olivier

et al. 2015

European Journal of Pharmacology

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Bipolar disorder is a unique illness characterized by fluctuations between mood states of depression and mania. Originally, an adrenergic-cholinergic balance hypothesis was postulated to underlie these different affective states. In this review, we update this hypothesis with recent findings from human and animal studies, suggesting that a catecholaminergic-cholinergic hypothesis may be more relevant. Evidence from neuroimaging studies, neuropharmacological interventions, and genetic associations support the notion that increased cholinergic functioning underlies depression, whereas increased activations of the catecholamines (dopamine and norepinephrine) underlie mania. Elevated functional acetylcholine during depression may affect both muscarinic and nicotinic acetylcholine receptors in a compensatory fashion. Increased functional dopamine and norepinephrine during mania on the other hand may affect receptor expression and functioning of dopamine reuptake transporters. Despite increasing evidence supporting this hypothesis, a relationship between these two neurotransmitter systems that could explain cycling between states of depression and mania is missing. Future studies should focus on the influence of environmental stimuli and genetic susceptibilities that may affect the catecholaminergic-cholinergic balance underlying cycling between the affective states. Overall, observations from recent studies add important data to this revised balance theory of bipolar disorder, renewing interest in this field of research.

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The flinders sensitive line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat

Cited by 14 publications

References 21 publications

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

Nicotinic systems and cognitive function

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

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