The fluorescence imaging and precise suppression of bacterial infections in chronic wounds by porphyrin-based metal–organic framework nanorods

Abstract

Nano-antibacterial agents play a critical role in chronic wound management. However, an intelligent nanosystem that can provide both visual warning of infection and precise sterilization remains a hurdle. Herein, a...

Recent advances in responsive hydrogels for diabetic wound healing

“…A series of pathophysiological changes accompany the different wound healing stages, and the microenvironmental pH is constantly and dynamically altered [ 62 ]. The normal pH of the skin is weakly acidic (5.5–6) [ 63 ], but chronic wounds have an elevated pH on their surface due to microvascular leakage [ 64 ]. As a result, the pH on the surface of chronic wounds becomes more alkaline, which can cause increased inflammation of the wound, resulting in a prolonged failure to heal.…”

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“…Notably, these Zn–TCPP nanorods could initiate fluorescence-imaging-guided PDT inactivation of microbes in a highly efficient way. 178…”

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“…Compared with single photon emission computed tomography imaging, the cyclotron that is employed for the generation of radionuclides is closer to the equipment of positron emission tomography due to the short lifetime of nuclides (e.g., minutes to hours). [42] In single photon emission computed tomography (SPECT) imaging, isotopes (e.g., 67 Ga, 99 mTc, 111 In, 123 I, etc.) can directly produce 𝛾-rays.…”