The Fluorodeoxyglucose 18F Scan in Alzheimer's Disease and Multi-infarct Dementia

Df, Benson; De, Kuhl; Ra, Hawkins; Phelps, M.E.; Jl, Cummings; Sy, Tsai

doi:10.1001/archneur.1983.04050110029003

Cited by 374 publications

(117 citation statements)

References 20 publications

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“…3. The first (peaks Ϫ9,Ϫ35, 40 and 7, Ϫ29, 40) was located somewhat more specifically in posterior cingulate gyrus than our a priori region, and was chosen because the posterior cingulate is a frequent focus in fluorodeoxyglucose positron emission tomography studies of aging and DAT (13)(14)(15)(16)(17). A second, more dorsal and posterior region located primarily in precuneus (peaks Ϫ7, Ϫ49, 52 and 9, Ϫ43, 44) was included because it contained the medial cortex voxels of highest significance in the between-group comparisons.…”

Section: Resultsmentioning

confidence: 99%

“…Functional activation of the medial parietal͞posterior cingulate in DAT may at first seem counterintuitive, given its strong association with DAT-related reductions in resting metabolism (13)(14)(15)(16)(17). However, in the schizophrenia literature there are also reports of patients showing functional activations in regions where control subjects show deactivations and that correspond to regions where patients have reduced resting metabolism (41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

“…Relevant to aging research, regions corresponding to those that show functional deactivations in young adults show reduced resting metabolism (measured by using fluorodeoxyglucose positron emission tomography) with aging, and this hypometabolism is even more pronounced in DAT (13)(14)(15)(16)(17). For example, a large multicenter study (n ϭ 505) found inverse correlations between age and resting metabolism in the medial frontal cortex for adults without dementia (15).…”

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confidence: 99%

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Functional deactivations: Change with age and dementia of the Alzheimer type

Lustig

Snyder²,

Bhakta

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

676

508

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Young adults typically deactivate specific brain regions during active task performance. Deactivated regions overlap with those that show reduced resting metabolic activity in aging and dementia, raising the possibility of a relation. Here, the magnitude and dynamic temporal properties of these typically deactivated regions were explored in aging by using functional MRI in 82 participants. Young adults (n ‫؍‬ 32), older adults without dementia (n ‫؍‬ 27), and older adults with early-stage dementia of the Alzheimer type (DAT) (n ‫؍‬ 23) were imaged while alternating between blocks of an active semantic classification task and a passive fixation baseline. Deactivation in lateral parietal regions was equivalent across groups; in medial frontal regions, it was reduced by aging but was not reduced further by DAT. Of greatest interest, a medial parietal͞ posterior cingulate region showed differences between young adults and older adults without dementia and an even more marked difference with DAT. The temporal profile of the medial parietal͞posterior cingulate response suggested that it was initially activated by all three groups, but the response in young adults quickly reversed sign, whereas DAT individuals maintained activation throughout the task block. Exploratory whole-brain analyses confirmed the importance of medial parietal͞posterior cingulate cortex differences in aging and DAT. These results introduce important opportunities to explore the functional properties of regions showing deactivations, how their dynamic functional properties relate to their baseline metabolic rates, and how they change with age and dementia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Functional deactivations: Change with age and dementia of the Alzheimer type

Lustig

Snyder²,

Bhakta

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

676

508

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“…Metabolic dysfunction in multiinfarct dementia shows less distinct anatomical prediction, and met abolic alterations are usually scattered all over the brain (Benson et al, 1983). …”

Section: Methodsmentioning

confidence: 99%

“…Standardized regional quanti tation was achieved using an interactive mapping pro gram (Herholz et aI., 1985). A categorical region matching and block shifting procedure (Pawlik et aI., 1986) provided optimal comparability both among sub- (Ferris et al, 1980;Benson et al, 1983;De Leon et al, 1983;Friedland et al, 1985;Cutler et al, 1985).…”

Section: Methodsmentioning

confidence: 99%

Effect of Piracetam on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured by Positron Emission Tomography

Heiss¹,

Hebold²,

Klinkhammer³

et al. 1988

J Cereb Blood Flow Metab

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Summary:The effect of piracetam (a putative enhancer of cerebral metabolism) on regional CMRalu was studied by positron emission tomography of 2[18Fl-fluoro-2-deoxY-D-glucose in nine patients with Alzheimer's dis ease, and in seven cases with multiinfarct dementia or unclassified dementia. In Alzheimer's disease, i. v. ad ministration of piracetam, 6 g b.i.d. for 2 weeks, signifi cantly improved rCMRalu in most cortical areas, whereas no effect on CMRalu of the drug was observed in the mul tiinfarct dementia/unclassified dementia groups. These

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Iofetamine I 123 Single Photon Emission Computed Tomography Is Accurate in the Diagnosis of Alzheimer's Disease

Johnson¹

1990

Arch Intern Med

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The Fluorodeoxyglucose 18F Scan in Alzheimer's Disease and Multi-infarct Dementia

Cited by 374 publications

References 20 publications

Functional deactivations: Change with age and dementia of the Alzheimer type

Functional deactivations: Change with age and dementia of the Alzheimer type

Effect of Piracetam on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured by Positron Emission Tomography

Iofetamine I 123 Single Photon Emission Computed Tomography Is Accurate in the Diagnosis of Alzheimer's Disease

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