The Force Degradation Study of The Morpholinium 2-((4-(2-Methoxyphenyl)-5-(Pyridin-4-YL)-4H-1,2,4-Triazol-3-YL) Thio)  Acetate

Varynskyi, B. O.; Kaplaushenko, A. G.

doi:10.14499/indonesianjpharm30iss1pp25

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Researchers from Ukraine are also looking for promising pharmacophores among 1,2,4-triazole derivatives. This is confirmed by articles [1][2][3][4][5][6][7][8][9][10]. Scientists are engaged in the synthesis [1][2][3][4][5][6], study of biological [1,2,5] action and analysis [7][8][9][10] of synthesized compounds based on 1,2,4-triazole nucleus.…”

Section: Introductionmentioning

confidence: 89%

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

et al. 2022

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The authors are not native speakers of Turkish The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.

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Section: Introductionmentioning

confidence: 89%

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

et al. 2022

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“…After analyzing a number of scientific studies of scientists , we can conclude that studies of 1,2,4-triazole derivatives occupy an important place in the Ukrainian pharmaceutical industry [27][28][29][30][31][32]. The articles show that scientists have a fairly broad approach to the modification of 1,2,4-triazole heterocycle [27][28][29][30].…”

Section: Figure 15mentioning

confidence: 99%

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

SAMELİUK¹,

Kaplaushenko²,

Zedan³

2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: Development of methods for the synthesis, studies of chemical, physico-chemical and biological properties of 1,2,4-triazole derivatives, in particular compounds with heterocyclic scaffolds and complex compounds as potential biologically active substances.Result and Discussion: In this review, 40 scientific papers reporting the properties of 1,2,4-triazole derivatives were evaluated. Each class of compounds described in the review was reported with the prospect of forming the direction for further research.Because of there is no enough studies about biological action of 1,2,4-triazole derivatives in human, it encourages further research.

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Metabolism study of morpholinium 2- ((4- (2-methoxyphenyl)-5-(pyridin-4-yl) -4H-1,2,4-triazole-3-yl)thio) acetate

Varynskyi

Kaplaushenko

2020

Current Issues in Pharmacy and Medical Sciences

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AbstractAim. The purpose of this study is to reveal the determination of the structure of the main metabolite of morpholinium 2-(4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-yl)thio)acetate (an active pharmaceutical ingredient – API) by way of chromatography through mass spectrometry detection, utilizing the liquid chromatography system Agilent 1260 Infinity and mass spectrometry detector (single quadrupole detector Agilent 6120). In the work, the graph of the change in the area of the peak of the metabolite from time after the introduction of the API solution was constructed. Moreover, the charges on the atoms of 2-((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio) acetate were calculated and the structure of the methyl derivative was proposed. We saw that the methylation of the active substance during metabolism formed a 5-((carboxymethyl)thio)-4-(2-methoxyphenyl)-1-methyl-3-(pyridin-4-yl)-4H-1,2,4-triazol-1-um cation through N-methyltransferase.

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The Force Degradation Study of The Morpholinium 2-((4-(2-Methoxyphenyl)-5-(Pyridin-4-YL)-4H-1,2,4-Triazol-3-YL) Thio) Acetate

Cited by 4 publications

References 6 publications

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

Metabolism study of morpholinium 2- ((4- (2-methoxyphenyl)-5-(pyridin-4-yl) -4H-1,2,4-triazole-3-yl)thio) acetate

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