The Four‐Component Reaction and Other Multicomponent Reactions of the Isocyanides

Abstract

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An Efficient Synthesis of Symmetric and Unsymmetric Bis-(β-aminoamides) via Ugi Multicomponent Reaction

“…The most puzzling situation is in the first example of an Ugi reaction in which a carboxylic acid has been replaced with water, reported by Ugi himself, in order to obtain the local anesthetic xylocaine ( 5 ) in an one-pot process. To accomplish this reaction a strong excess of hydrochloric acid was used (Scheme ).…”