The FoxO-subclass in Xenopus laevis development

Pohl, Barbara; Schön, Christian; Rossner, Antje; Knöchel, Walter

doi:10.1016/j.modgep.2004.08.009

Cited by 17 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The forkhead box transcription factor p1 is a member of the FoxP subclass. In Xenopus, zygotic transcription starts at stage 26 and continues throughout embryogenesis (Shu et al, 2001;Li et al, 2004;Pohl et al, 2004). At tailbud stages (26-32), FoxP1 expression is visible in regions of the brain, eyes, and splachnic mesodermal layer.…”

Section: Anteroposterior Subdivisionsmentioning

confidence: 99%

“…At tailbud stages (26-32), FoxP1 expression is visible in regions of the brain, eyes, and splachnic mesodermal layer. For the brain, its expression domain was described to be restricted to the outer region of the mesencephalon (Pohl et al, 2004). Previous studies in mice also misinterpreted its expression as lying within the midbrain (Shu et al, 2001;Tamura et al, 2003).…”

Section: Anteroposterior Subdivisionsmentioning

confidence: 99%

See 1 more Smart Citation

Embryonic genoarchitecture of the pretectum in Xenopus laevis: A conserved pattern in tetrapods

et al. 2011

View full text Add to dashboard Cite

Networked gene activities control the evolutionarily conserved histogenetic organization of the central nervous system of vertebrates. Genoarchitectonic studies contribute to the analysis of each morphogenetic field by identifying distinct progenitor domains and corresponding derivatives whose pattern of gene expression shows a unique combinatory code. Previous studies in the pretectal region (caudal diencephalon) have defined three anteroposterior genoarchitectonic domains that are conserved in birds and mammals. Here, we have studied the embryonic pretectal genoarchitecture in the amphibian Xenopus laevis, in order to determine whether it is possible to define a comparable anteroposterior tripartition of the amphibian pretectal area. The expression patterns of 14 genes mapped from early embryonic stages to metamorphic climax allowed us to define the boundaries of the pretectum, the expected precommissural, juxtacommissural, and commissural anteroposterior domains, and some dorsoventral subdivisions. Taken together, our data provide evidence for a conserved pattern of pretectal domains and subdomains, shared by amniotes and amphibian anamniotes (tetrapods), understandable as part of a general Bauplan in vertebrates.

show abstract

Section: Anteroposterior Subdivisionsmentioning

confidence: 99%

Section: Anteroposterior Subdivisionsmentioning

confidence: 99%

Embryonic genoarchitecture of the pretectum in Xenopus laevis: A conserved pattern in tetrapods

et al. 2011

View full text Add to dashboard Cite

show abstract

“…response to insulin signaling at Thr24, Ser256, Ser319, and Ser329. Examination of the X. laevis FoxO1 sequence identified the comparable residues as being Thr28, Ser245, Ser308, and Ser318 (Pohl et al, 2004). FoxO1 phosphorylation status in response to dehydration in X. laevis was examined using a FoxO1 ser256 anti-rabbit antibody that recognized the homologous Ser245 site in the frog liver protein, crossreacting with a single protein band in frog liver extracts at the expected molecular weight of~82 kDa.…”

Section: Foxo1 Total Protein Nuclear Localization and Dna Binding Amentioning

confidence: 99%

Transcriptional regulation of antioxidant enzymes by FoxO1 under dehydration stress

Malik

Storey

2011

Gene

View full text Add to dashboard Cite

“…Evidence for a role of FOXO factors in embryonic development has also been provided in the frog Xenopus laevis, where xfoxo1 and xfoxo3 (foxo orthologs) present distinct spatial and temporal patterns of expression (Pohl et al 2004). …”

Section: Cell Functions Regulated By Foxomentioning

confidence: 99%

The emerging role of FOXO transcription factors in pancreatic β cells

Glauser

Schlegel

2007

Journal of Endocrinology

134

105

View full text Add to dashboard Cite

FOXO transcription factors critically control fundamental cellular processes, including metabolism, cell differentiation, cell cycle arrest, DNA repair, and other reactions to cellular stress. FOXO factors sense the balance between stimuli promoting growth and differentiation versus stress stimuli signaling damage. Integrated through the FOXO system, these divergent stimuli decide on cell fate, a choice between proliferation, differentiation, or apoptosis. In pancreatic b cells, most recent evidence highlights complex FOXOdependent responses to glucose, insulin, or other growth factors, which include regulatory feedback. In the short term, FOXO-dependent mechanisms help b cells to accomplish their endocrine function, and may increase their resistance to oxidative stress due to transient hyperglycemia. In the long term, FOXO-dependent responses lead to the adaptation of b cell mass, conditioning the future ability of the organism to produce insulin and cope with changes in fuel abundance. FOXO emerges as a key factor for the maintenance of a functional endocrine pancreas and represents an interesting element in the development of therapeutic approaches to treat diabetes. This review on the role of FOXO transcription factors in pancreatic b cells has three parts. In Part I, FOXO transcription factors will be presented in general: structure, molecular mechanisms of regulation, cellular functions, and physiological roles. Part II will focus on specific data about FOXO factors in pancreatic b cells. Lastly in Part III, it will be attempted to combine general and b cell-specific knowledge with the aim to envisage globally the role of FOXO factors in b cell-linked physiology and disease. The DNA-binding domain (Forkhead box) is located in the N-terminal portion of these proteins, while the transactivation domain is located in the C-terminal portion. Furthermore, a 'nuclear export sequence' and a 'nuclear localization signal' have been delineated. These motifs allow FOXO factors to shuttle in and out of the nucleus (see below). FOXO proteins may be post-translationally modified by phosphorylation and/or acetylation at differentially conserved serine/threonine and lysine residues respectively. Structural features of FOXO proteins have been detailed in recent reviews (Barthel et al. 2005, Greer & Brunet 2005. Molecular regulation of FOXO transcription factorsAs illustrated in Fig. 1, multiple molecular mechanisms regulate FOXO transcription factor functions. Some control subcellular FOXO localization, while others modulate FOXO transactivation properties. Furthermore, FOXO factor abundance is regulated by site-specific protein cleavage or through the control of foxo gene expression.Subcellular localization FOXO factors shuttle between nucleus and cytoplasm. This represents a major event controlling FOXO activity that results from changes in FOXO phosphorylation. Two main classes of stimuli trigger FOXO phosphorylation with opposing effects on FOXO localization.

show abstract

The FoxO-subclass in Xenopus laevis development

Cited by 17 publications

References 24 publications

Embryonic genoarchitecture of the pretectum in Xenopus laevis: A conserved pattern in tetrapods

Embryonic genoarchitecture of the pretectum in Xenopus laevis: A conserved pattern in tetrapods

Transcriptional regulation of antioxidant enzymes by FoxO1 under dehydration stress

The emerging role of FOXO transcription factors in pancreatic β cells

Contact Info

Product

Resources

About