The fragment-approach: An update

Bartoli, Sandra; Fincham, Christopher I.; Fattori, Daniela

doi:10.1016/j.ddtec.2006.12.001

Cited by 18 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The technique is often performed in academic institutions and small pharmaceutical companies where no HTS screening capacity is available [163][164][165][166][167][168][169][170][171][172][173][174][175]. However, there is now an increasing number of examples in the literature that demonstrate that fragment-based discovery can identify quality leads for targets where HTS has not succeeded [176].…”

Section: Fragment-based Screeningmentioning

confidence: 99%

Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery

Dalvit

2007

Progress in Nuclear Magnetic Resonance Spectroscopy

181

142

View full text Add to dashboard Cite

Section: Fragment-based Screeningmentioning

confidence: 99%

Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery

Dalvit

2007

Progress in Nuclear Magnetic Resonance Spectroscopy

181

142

View full text Add to dashboard Cite

“…A number of review articles illustrate how optical biosensors, along with complementary biochemical and biophysical techniques, have furthered our understanding of protein interactions [50,[56][57][58]61,63,67,79,80,86], as well as the characterization of carbohydrates [55,78,82], oligonucleotides [91], membranes, lipids, films, and other biological interfaces [53,59,68,74,75,83,87,92]. Other reviews demonstrate the biosensor's contribution in basic research of small molecules [73] and antibodies [62,65,71,88], as well as the development of small-molecule drugs and protein therapeutics [49,52,54,89,90]. Several authors demonstrate the biosensor's escalating role in two areas: (1) food composition/contamination and environment/food safety [51,64,70,72] and (2) detection of viruses and bacteria as emerging disease elements and biological warfare agents [66,76,77,81,85].…”

Section: Reviewsmentioning

confidence: 99%

Survey of the year 2006 commercial optical biosensor literature

Rich

Myszka

2007

J of Molecular Recognition

110

View full text Add to dashboard Cite

We identified 1219 articles published in 2006 that described work performed using commercial optical biosensor platforms. It is interesting to witness how the biosensor market is maturing with an increased number of instrument manufacturers offering a wider variety of platforms. However, it is clear from a review of the results presented that the advances in technology are outpacing the skill level of the average biosensor user. While we can track a gradual improvement in the quality of the published work, we clearly have a long way to go before we capitalize on the full potential of biosensor technology. To illustrate what is right with the biosensor literature, we highlight the work of 10 groups who have their eye on the ball. To help out the rest of us who have the lights on but nobody home, we use the literature to address common myths about biosensor technology.

show abstract

“…Fragment-based drug discovery (FBDD) is a relatively new approach to compound library creation, screening efforts and hit triage that seeks to * [3][4][5][6][7][8][9][10]. Hann et al have established that there is a higher probability of finding a molecular entity that binds to a target if it has a low molecular weight and is relatively less complex [11].…”

Section: Introductionmentioning

confidence: 99%

Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery

Reitz¹,

Smith²,

Tounge³

et al. 2009

CTMC

View full text Add to dashboard Cite

Fragment-based drug discovery (FBDD) is an important new tool to understand the molecule basis of ligand-biological target interactions. By combining optimal fragments, it is often possible to construct larger molecular weight compounds that have greater potency in a shorter period of time than can been achieved by the initial screening of larger molecular weight compound libraries. Alternatively, if screening of more traditional larger libraries has occurred, then it may be possible to analyze the data during the process of hit triage in such as way as to essentially adopt a fragment-based approach in reverse. In this review, we highlight general principles associated with the efficiency indices such as Ligand Efficiency (LE) in which screening data is normalized for biophysical properties such as molecular size. We further focus on the concept of Fit Quality (FQ), which standardizes LE values across molecular weight for more realistic, direct comparison. Using these simple concepts, one can apply FBDD routinely in the stage of hit triage when evaluating the data obtained after screening of compound libraries in drug discovery.

show abstract

The fragment-approach: An update

Cited by 18 publications

References 32 publications

Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery

Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery

Survey of the year 2006 commercial optical biosensor literature

Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery

Contact Info

Product

Resources

About