The FRIGIDA Complex Activates Transcription of <i>FLC</i>, a Strong Flowering Repressor in <i>Arabidopsis</i>, by Recruiting Chromatin Modification Factors

Choi, Kyuha; Kim, Ju-Hyun; Hwang, Hye Jeon; Kim, Sanghee; Park, Chulmin; Kim, Sang Yeol; Lee, Ilha

doi:10.1105/tpc.110.075911

Cited by 302 publications

(311 citation statements)

References 61 publications

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“…A later study reported a binding motif that is involved in recognition of the FLC promoter by SUF4, a component of the FRIGIDA complex that increases FLC transcription in A. thaliana (Choi et al . 2011). However, the binding motif, which is located upstream of the minimal promoter (Sheldon et al .…”

Section: Discussionmentioning

confidence: 99%

Divergence of annual and perennial species in the Brassicaceae and the contribution of cis‐acting variation at FLC orthologues

Kiefer

Severing

Karl³

et al. 2017

Molecular Ecology

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Variation in life history contributes to reproductive success in different environments. Divergence of annual and perennial angiosperm species is an extreme example that has occurred frequently. Perennials survive for several years and restrict the duration of reproduction by cycling between vegetative growth and flowering, whereas annuals live for 1 year and flower once. We used the tribe Arabideae (Brassicaceae) to study the divergence of seasonal flowering behaviour among annual and perennial species. In perennial Brassicaceae, orthologues of FLOWERING LOCUS C (FLC), a floral inhibitor in Arabidopsis thaliana, are repressed by winter cold and reactivated in spring conferring seasonal flowering patterns, whereas in annuals, they are stably repressed by cold. We isolated FLC orthologues from three annual and two perennial Arabis species and found that the duplicated structure of the A. alpina locus is not required for perenniality. The expression patterns of the genes differed between annuals and perennials, as observed among Arabidopsis species, suggesting a broad relevance of these patterns within the Brassicaceae. Also analysis of plants derived from an interspecies cross of A. alpina and annual A. montbretiana demonstrated that cis‐regulatory changes in FLC orthologues contribute to their different transcriptional patterns. Sequence comparisons of FLC orthologues from annuals and perennials in the tribes Arabideae and Camelineae identified two regulatory regions in the first intron whose sequence variation correlates with divergence of the annual and perennial expression patterns. Thus, we propose that related cis‐acting changes in FLC orthologues occur independently in different tribes of the Brassicaceae during life history evolution.

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Section: Discussionmentioning

confidence: 99%

Divergence of annual and perennial species in the Brassicaceae and the contribution of cis‐acting variation at FLC orthologues

Kiefer

Severing

Karl³

et al. 2017

Molecular Ecology

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“…SUF4 is a zinc finger-containing TF that is required for delayed flowering by promoting the FLC expression. SUF4 binds to a cis-element of the FLC promoter and acts as part of the transcriptional activator complex 35 .…”

Section: Med18 Contributes To Plant Defence Against Necrotrophsmentioning

confidence: 99%

MED18 interaction with distinct transcription factors regulates multiple plant functions

et al. 2014

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Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5. Consequently, yy1 and med18 mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSEN-SITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the med18 mutant, reinforcing MED18 function in different mechanisms of transcriptional control. Overall, MED18 conveys distinct cues to engender transcription underpinning plant responses.

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“…The epigenetic regulation of FLC by vernalisation has been extensively studied and should pave the way to discover new insights into the epigenetic regulatory mechanisms controlling CRTISO expression and perhaps link carotenoids with the developmental regulation of floral initiation (Dennis and Peacock 2007). It was recently demonstrated that SDG8 interacts with FRIGIDA (FRI), a protein that delays flowering by activating FLC expression and in the absence of a prolonged cold winter period (a process known as vernalisation) FRI promotes a vegetative state of growth (Choi et al 2011). SDG8 is essential for FRI function and SDG8 was recently demonstrated to have a novel dual substrate specificity for H3K4 and H3K36 specific histone lysine methylation activity (Ko et al 2010).…”

Section: Epigenetic Maintenance Of Carotenoid Compositionmentioning

confidence: 99%

Carotenoids in nature: insights from plants and beyond

Cazzonelli

2011

Functional Plant Biol.

442

245

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Abstract. Carotenoids are natural isoprenoid pigments that provide leaves, fruits, vegetables and flowers with distinctive yellow, orange and some reddish colours as well as several aromas in plants. Their bright colours serve as attractants for pollination and seed dispersal. Carotenoids comprise a large family of C 40 polyenes and are synthesised by all photosynthetic organisms, aphids, some bacteria and fungi alike. In animals carotenoid derivatives promote health, improve sexual behaviour and are essential for reproduction. As such, carotenoids are commercially important in agriculture, food, health and the cosmetic industries. In plants, carotenoids are essential components required for photosynthesis, photoprotection and the production of carotenoid-derived phytohormones, including ABA and strigolactone. The carotenoid biosynthetic pathway has been extensively studied in a range of organisms providing an almost complete pathway for carotenogenesis. A new wave in carotenoid biology has revealed implications for epigenetic and metabolic feedback control of carotenogenesis. Developmental and environmental signals can regulate carotenoid gene expression thereby affecting carotenoid accumulation. This review highlights mechanisms controlling (1) the first committed step in phytoene biosynthesis, (2) flux through the branch to synthesis of a-and b-carotenes and (3) metabolic feedback signalling within and between the carotenoid, MEP and ABA pathways.

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The FRIGIDA Complex Activates Transcription of FLC, a Strong Flowering Repressor in Arabidopsis, by Recruiting Chromatin Modification Factors

Cited by 302 publications

References 61 publications

Divergence of annual and perennial species in the Brassicaceae and the contribution of cis‐acting variation at FLC orthologues

Divergence of annual and perennial species in the Brassicaceae and the contribution of cis‐acting variation at FLC orthologues

MED18 interaction with distinct transcription factors regulates multiple plant functions

Carotenoids in nature: insights from plants and beyond

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