The Function and Therapeutic Implications of TNF Signaling in MDSCs

Abstract

Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The accumulation and activation of MDSCs can be regulated by tumor necrosis factor α (TNF-α). In this review, we summarize the roles played by TNF-α in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-α upon these cells in tumor growth and some inflammatory disorders.

Natural Killer Cells Reprogram Myeloid-Derived Suppressor Cells to Induce TNF-α Release via NKG2D–Ligand Interaction after Cryo-Thermal Therapy

“…Moreover, TNF-α and IFN-γ could induce high levels of CD40 on mature MDSCs through interacting with CD40L on T cells after CTT to promote Th1-dominant CD4 + T cell differentiation and orchestrate CTTinduced long-term anti-tumor immunity. Both MDSCs and NK cells can produce TNF-α for immunomodulation [17,22,42]. In the present study, we discovered that the in vitro culture of either MDSCs or NK cells alone produced a small amount of TNF-α.…”