The Function of Body Mass Index in the Older with Osteosarcopenia: A Systematic Review and Meta-analysis

Abstract

Background Due to the aging population worldwide, diseases that frequently attack elderly people, such as sarcopenia and osteoporosis, are major public health issues. Methods This study used a systematic review and meta-analysis to examine the associations among body mass index (BMI), sarcopenia, and bone mineral density (BMD) in a group of adults older than 60 years. Eight studies with a total of 18,783 subjects were examined using a random effect model. Results In sarcopenia patients, total hip BMD (d=0.560; 95% confidence interval [CI], 0.438 to 0.681; P <0.01; I 2 =53.755%), femoral neck BMD (d=0.522; 95% CI, 0.423 to 0.621; P <0.01; I 2 =77.736%) and lumbar spine BMD (d=0.295; 95% CI, 0.111 to 0.478; P <0.01; I 2 =66.174%) were lower than in control subjects. Additionally, BMI (d=0.711; 95% CI, 0.456 to 0.996; P <0.01; I 2 =97.609%) correlated with the BMD of the total hip, femoral neck, and lumbar spine. That is, sarcopenia patients with low BMD levels in the total hip, femoral neck, and lumbar spine also had low fat levels. Thus, sarcopenia patients with low BMD in the total hip, femoral neck and lumbar spine and low BMI could have a higher than average risk of osteosarcopenia. No sex effects were significant ( P >0.05) for any variable. Conclusion BMI could be a key point in osteosarcopenia, suggesting that a low body weight could be facilitate the transition from sarcopenia to osteosarcopenia.

Contact states with femoral cortical bone and periprosthetic bone mineral density changes differ between traditional and newly introduced fully hydroxyapatite-coated stems

“…Furthermore, the change of BMD around either fully HA-coated stem did not correlate with the contact with the femoral cortical bone, but with factors related to the systemic quality of bone quality, such as the BMI and the lumbar BMD. 23,24 In a study comparing bony ingrowth and attachment to the surfaces of implants between retrieved plain porous-coated and porous HA-coated stems using light morphometric techniques, HA coating increased the amount of bony ingrowth and attachment. 25 Delaunay 26 reported that HA coating ameliorated proximal osteopenia and BMD decreased when HA-coated and non-HA-coated stems with the same geometry were compared.…”