The function of LncRNA-ATB in cancer

Anbiyaiee, Amir; Ramazii, Mohammad; Bajestani, Siamak Soltani; Meybodi, Seyed Mohammadmahdi; Keivan, Mona; Khoshnam, Seyed Esmaeil; Farzaneh, Maryam

doi:10.1007/s12094-022-02848-1

Cited by 15 publications

(3 citation statements)

References 82 publications

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“…Therefore, it is urgent to mine corresponding targeted genes, explore potential molecular mechanisms, and identify biomarkers. 4 In recent years, a large number of studies have found abnormal expression of long noncoding RNA (lncRNA) in tumor tissues, 5 , 6 , 7 , 8 in which a considerable part of lncRNA molecules are closely related to the occurrence and development of GC. 9 , 10 , 11 lncRNA, 12 , 13 , 14 as a functional RNA molecule, does not encode proteins, but influences the expression of protein-coding genes by recruiting or isolating gene regulatory proteins, and expresses specific gene expression patterns during cancer development.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

Zhang,

Li,

Fan

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

“…. 20 , 21 , 22 Studies show that THUMPD3-AS1 is involved in the occurrence and development of lung cancer and colorectal cancer, and is closely related to lymphatic metastasis and other risk factors. However, its specific role and mode of action in GC are still not completely clear.…”

Section: Introductionmentioning

confidence: 99%

LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

Zhang,

Li,

Fan

et al. 2023

iScience

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“…The increased expression of lnc-ATB correlates with a larger tumor size, vascular invasion, and lymph node metastasis in CRC, and its regulation of β-catenin maintains CRC cell stemness. Elevated plasma lnc-ATB has been proposed as a significant biomarker for distinguishing CRC patients, emphasizing its potential role in CRC diagnosis, prognosis, and immune interplay [ 115 , 116 , 117 ].…”

Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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