The Function of the Caudate Nucleus in the Control of Some Paroxystic Activities in the Neuraxis

Amato, Giuseppe; Grutta, V La; Militello, L.; Enia, Francesco

doi:10.3109/13813456909069825

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…These latter receptors are mainly represented in the spinal cord and brainstem 13 , and might be involved in the myorelaxant activity of thiocolchicoside 8 . GABA A receptors, instead, are mainly represented in the cerebral cortex 14,15 , and may be involved both in the convulsant activity of thiocolchicoside, and in spiking produced by strychnine in the cortex 16 . In particular, the convulsant activity of thiocolchicoside is likely to involve an overcoming effect of thiocolchicoside antagonism at a subset of GABA A receptors, on thiocolchicoside inhibitory effects of allosteric activation of strychnine-sensitive glycine receptors.…”

Section: Discussionmentioning

confidence: 99%

Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat

Sechi¹,

Riu

Mameli

et al. 2003

Seizure

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The objective of this study was to document the convulsant properties of thiocolchicoside in rats, and to characterise the electroclinical pattern of epileptic seizures. Experiments were carried out in three groups of male Wistar rats: in group A, thiocolchicoside was applied topically to the pia, or given by microinjection to the cerebral cortex (2 microg/microl); in group B, the drug was administered parenterally (6 mg/kg) to rats with minimal lesions of the dura and arachnoid membranes; in group C, thiocolchicoside was administered parenterally (up to 12 mg/kg) to intact rats. In all animals, electroclinical activity was continuously monitored for at least 3 hours after thiocolchicoside injection or application. In group A, electrographic and behavioural activity of focal motor seizures occurred in 100% of animals, developing into a focal status epilepticus; in group B, a multifocal epileptic pattern with secondary generalisation, clinically characterised by clonic or tonic-clonic seizures occurred in 100% of animals, until a secondarily generalised convulsive status epilepticus; in group C, none of animals showed either electrographic or behavioural seizure activity. Our study documents that thiocolchicoside has a powerful convulsant activity in the rat, perhaps due to an antagonistic interaction of the compound with a cortical subtype of the GABA(A) receptor.

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