The Function of the Novel Mechanical Activated Ion Channel Piezo1 in the Human Osteosarcoma Cells

Jiang, Long; Zhao, Yiding; Chen, Weixiang

doi:10.12659/msm.906959

Cited by 39 publications

(26 citation statements)

References 21 publications

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“…Hypoperfusion and hypoxia lower the efficacy of tumour targeted drug delivery, promoting immune evasion and tumour metastasis. Evidence has shown that expression of PIEZO1 increased in multiple malignant diseases including bladder carcinoma, synovial sarcoma, osteosarcoma, breast cancer and gastric cancer 12,[46][47][48][49] . PIEZO1 is also involved in 2D cell migration and 3D invasion in the MCF-7 cell line, a gastric cancer cell line, and small-cell lung carcinoma cell lines 12,33,49 .…”

Section: Discussionmentioning

confidence: 99%

Identification of PIEZO1 as a potential prognostic marker in gliomas

Zhou

Liu

Wijnbergen

et al. 2020

Sci Rep

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In multiple solid tumours, including gliomas, the mechanical properties change as the disease progresses. If and how mechanical cues regulate tumour cell proliferation is currently not fully studied. PIEZO1 has recently been identified as a crucial mechanosensitive cation channel in multiple solid tumours. However, we didn’t find any clinical data describing the association between PIEZO1 expression and glioma. To investigate the role of PIEZO1 in gliomas, we analysed PIEZO1 gene expression at the transcriptome level, genomic profiles and the association of PIEZO1 with clinical practice. In total, 1633 glioma samples with transcriptome data, including data from the Chinese Glioma Genome Atlas RNAseq, the Cancer Genome Atlas RNAseq and GSE16011 databases, were included in this study. Clinical information and genomic profiles including somatic mutations were also obtained. We found that PIEZO1 expression was highly correlated with malignant clinical and molecular subtypes of glioma. Gene ontology analysis showed that expression of PIEZO1 was correlated with tumour microenvironment-related genes that encode proteins involved in extracellular matrix (ECM) organization, angiogenesis and cell migration. Additionally, PIEZO1 was shown to be involved in tumour progression by serving as the central checkpoint of multiple ECM remodelling-related signalling pathways to modulate tumour cell proliferation and the tumour microenvironment in turn. Finally, high PIEZO1 expression was correlated with reduced survival time and acted as a robust biomarker for poor prognosis in gliomas. Taken together, the results indicated that high PIEZO1 expression is closely associated with highly malignant gliomas. Importantly, PIEZO1 serves as a key factor involved in sensing mechanical properties in the tumour and can regulate both tumour cells and their microenvironment to promote glioma progression, and it is also a potential therapeutic target for the treatment of gliomas.

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Section: Discussionmentioning

confidence: 99%

Identification of PIEZO1 as a potential prognostic marker in gliomas

Zhou

Liu

Wijnbergen

et al. 2020

Sci Rep

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“…In addition, further in vivo experiments demonstrated that the suppression of Piezo1 gene expression enhanced tumor growth of such cells in immunocompromised mice. In brief, the results obtained in this study showed an oncosuppressive role for Piezo1 through Ca 2+ -induced apoptosis and the inhibition of the proliferative capability of OS cells [88].…”

Section: Osteosarcomamentioning

confidence: 52%

“…OS is often associated with aberrant mechanical features [87], thus, it is reasonable considering that MS channels, especially Piezo channels, may play an essential role in OS tumorigenesis. In a study carried out by Jiang and colleagues, Piezo1 channels were found overexpressed in human OS cells [88]. The data of in vitro experiments indicated that Piezo1 could mediate the mechanical stress, inducing apoptosis and inhibiting cell proliferation of OS cells.…”

Section: Osteosarcomamentioning

confidence: 97%

Mechanosensitive Piezo Channels in Cancer: Focus on altered Calcium Signaling in Cancer Cells and in Tumor Progression

Felice

Alaimo

2020

Cancers

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Mechanotransduction, the translation of mechanical stimuli into biological signals, is a crucial mechanism involved in the function of fundamentally all cell types. In many solid tumors, the malignant transformation is often associated with drastic changes in cell mechanical features. Extracellular matrix stiffness, invasive growth, and cell mobility are just a few hallmarks present in cancer cells that, by inducing mechanical stimuli, create positive feedbacks promoting cancer development. Among the molecular players involved in these pathophysiological processes, the mechanosensitive Ca2+-permeable Piezo channels have emerged as major transducers of mechanical stress into Ca2+ dependent signals. Piezo channels are overexpressed in several cancers, such as in breast, gastric, and bladder, whereas their downregulation has been described in other cancers. Still, the roles of mechanosensitive Piezos in cancer are somewhat puzzling. In this review, we summarize the current knowledge on the pathophysiological roles of these Ca2+-permeable channels, with special emphasis on their functional involvement in different cancer types progression.

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“…In addition, Piezo channel activation can deliver local Ca 2+ influx, thereby modulating key Ca 2+− dependent signaling pathways associated with cancer cell migration, proliferation, and angiogenesis (De Felice and Alaimo, 2020). Recent studies have noted the close correlation between the Piezo1 channel and some cancers, including gastric cancer, oral squamous cell carcinoma, prostate cancer, colon cancer, synovial sarcoma, and osteosarcoma (Jiang et al, 2017;Suzuki et al, 2018;Zhang et al, 2018;Han et al, 2019;Sun et al, 2020;Hasegawa et al, 2021;Wang et al, 2021). Piezo1-dependent mechanosensation has also been linked to immune regulation in the differentiation of suppressive myeloid cells that regulate cancer and infectious diseases (Aykut et al, 2020).…”

Section: Future Outlookmentioning

confidence: 99%

Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis

Guo

Zhao

et al. 2021

Front. Pharmacol.

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Purpose: We used bibliometric methods to evaluate the global scientific output of research on Piezo channels and explore the current status and trends in this field over the past decade.Methods: Piezo channel-related studies published in 2010–2020 were retrieved from Web of Science. The R bibliometrix package was used for quantitative and qualitative analyses of publication outputs and author contributions. VOSviewer was used to construct networks based on co-authorship of countries/institutions/authors, co-citation analysis of journals/references, citation analysis of documents, and co-occurrence of keywords.Results: In total, 556 related articles and reviews were included in the final analysis. The number of publications has increased substantially with time. The country and institution contributing the most to this field was the United States and Scripps Research Institute, respectively. Ardem Patapoutian was the most productive author and ranked first among the cited authors, h-index, and m-index. The top cited reference was the article published by Coste B et al. in Science (2010) that identified Piezo1/2 in mammalian cells. The top journals in terms of the number of selected articles and citations were Nature Communications and Nature, respectively. The co-occurrence analysis revealed that Piezo channels are involved a variety of cell types (Merkel cells, neurons, endothelial cells, red blood cells), physiological processes (touch sensation, blood pressure, proprioception, vascular development), related ion channels (transient receptor potential, Gardos), and diseases (pain, distal arthrogryposis, dehydrated hereditary stomatocytosis, cancer), and pharmacology (Yoda1, GsMTx-4).Conclusion: Our bibliometric analysis shows that Piezo channel research continues to be a hotspot. The focus has evolved from Piezo identification to architecture, activation mechanism, roles in diseases, and pharmacology.

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The Function of the Novel Mechanical Activated Ion Channel Piezo1 in the Human Osteosarcoma Cells

Cited by 39 publications

References 21 publications

Identification of PIEZO1 as a potential prognostic marker in gliomas

Identification of PIEZO1 as a potential prognostic marker in gliomas

Mechanosensitive Piezo Channels in Cancer: Focus on altered Calcium Signaling in Cancer Cells and in Tumor Progression

Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis

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