The functional connectivity of the human caudate: An application of meta-analytic connectivity modeling with behavioral filtering

Robinson, Jennifer L.; Laird, Angela R.; Glahn, David C.; Blangero, John; Sanghera, Manjit K.; Pessoa, Luiz; Fox, P. Mickle; Uecker, Angela M.; Friehs, Gerhard; Young, Kimball; Griffin, Jennifer L.; Lovallo, William R.; Fox, Peter T.

doi:10.1016/j.neuroimage.2011.12.010

Cited by 239 publications

(213 citation statements)

References 61 publications

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“…These results contrast with taxonomies based on nonhuman primate data (11), which locate the body of the caudate within an oculomotor circuit. They also diverge from the conclusions of a recent human metaanalysis (47), which associated the caudate head with cognition and emotion and the caudate body with perception and action. We also found further evidence for a previously underdiscussed dissociation between VS and Ca, such that the VS may be involved in representing available rewards and the Ca in representing the expected outcome of different actions (5,6).…”

Section: Discussioncontrasting

confidence: 92%

Regional specialization within the human striatum for diverse psychological functions

Pauli

O’Reilly

Yarkoni

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

179

156

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Decades of animal and human neuroimaging research have identified distinct, but overlapping, striatal zones, which are interconnected with separable corticostriatal circuits, and are crucial for the organization of functional systems. Despite continuous efforts to subdivide the human striatum based on anatomical and resting-state functional connectivity, characterizing the different psychological processes related to each zone remains a work in progress. Using an unbiased, data-driven approach, we analyzed large-scale coactivation data from 5,809 human imaging studies. We (i) identified five distinct striatal zones that exhibited discrete patterns of coactivation with cortical brain regions across distinct psychological processes and (ii) identified the different psychological processes associated with each zone. We found that the reported pattern of cortical activation reliably predicted which striatal zone was most strongly activated. Critically, activation in each functional zone could be associated with distinct psychological processes directly, rather than inferred indirectly from psychological functions attributed to associated cortices. Consistent with well-established findings, we found an association of the ventral striatum (VS) with reward processing. Confirming less well-established findings, the VS and adjacent anterior caudate were associated with evaluating the value of rewards and actions, respectively. Furthermore, our results confirmed a sometimes overlooked specialization of the posterior caudate nucleus for executive functions, often considered the exclusive domain of frontoparietal cortical circuits. Our findings provide a precise functional map of regional specialization within the human striatum, both in terms of the differential cortical regions and psychological functions associated with each striatal zone.human striatum | parcellation | corticostriatal circuits | coactivation analysis | NeuroSynth I n addition to its central role in selecting, planning, and executing motor behavior (1, 2), the human striatum has been reported to be involved in diverse psychological functions, including emotion generation and regulation (3, 4), reward-related processes and decision making (5, 6), and executive functions (7,8). These discrete functions are thought to map onto distinct functional striatal zones, which participate in separable basal ganglia-thalamocortical circuits (9-12) and are critical for the organization of behavior.Following this logic, recent attempts to parcellate the human striatum using diffusion tensor imaging (DTI) (13, 14) and restingstate functional connectivity (RSFC) (15-17) have relied on patterns of corticostriatal connectivity to identify striatal zones. Although very useful, these studies have been limited to inferring striatal function indirectly via psychological functions of connected cortical regions. In addition, it remains unclear how anatomical connections and RSFC map onto different psychological processes (18). Finally, RSFC is sometimes epiphenomenal (19), and f...

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Section: Discussioncontrasting

confidence: 92%

Regional specialization within the human striatum for diverse psychological functions

Pauli

O’Reilly

Yarkoni

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

179

156

View full text Add to dashboard Cite

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“…These areas, which are cognitive-and action-specific domains, have functional connection with the caudate tail, while the caudate head has a stronger functional connection with the prefrontal areas. 40 Further pathologic study is warranted to define different topographic areas involved within the caudate between the 2 groups. Our study has several limitations.…”

Section: Discussionmentioning

confidence: 99%

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Shin

Lee³

et al. 2015

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impairment in Parkinson disease. Therefore, our aim was to evaluate the different patterns of structural and functional changes in Parkinson disease with mild cognitive impairment according to the duration of parkinsonism before mild cognitive impairment.

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“…76 Changes in the construction of the human caudate by hydrocephalus or dementia can result in a variety of neurological and psychiatric disorders. 34,85 Thalamus…”

Section: Caudate Nucleusmentioning

confidence: 99%

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

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S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

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The functional connectivity of the human caudate: An application of meta-analytic connectivity modeling with behavioral filtering

Cited by 239 publications

References 61 publications

Regional specialization within the human striatum for diverse psychological functions

Regional specialization within the human striatum for diverse psychological functions

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

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