The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease

Nazifi, Masoomeh; Oryan, Shahrbanoo; Esfahani, Delaram Eslimi; Ashrafpoor, Manoochehr

doi:10.1016/j.lfs.2020.118802

Cited by 23 publications

(12 citation statements)

References 38 publications

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“…Given this, and since the swimming speed was the same among the groups, it could be assumed that the observed differences in memory function may not be related to confounding factors such as speci c differences in sensorimotor integration or motivation of the animals. Donepezil in combination with a variety of agents such as piperine (Nazi et al, 2021), resveratrol (Rao et al, 2021), estradiol (Gibbs et al, 2011), and manual acupuncture (Jiang et al, 2019) has been examined to achieve a superior bene t for neurobehavioral de cits in AD animal models. To date, there have been no attempts to address the potentials of donepezil administration and EE in combination for the prevention of cognitive de cits in AD patients or experimentally neurodegenerative status.…”

Section: Discussionmentioning

confidence: 99%

“…The combination of different interventions for achieving superior cognitive enhancement has appeared as a promising therapeutic approach in health and disease. In the case of cognitive de cits in AD and other experimental models, the combination of donepezil with some treatments including piperine (Nazi et al, 2021), resveratrol (Rao et al, 2021), estradiol (Gibbs et al, 2011), and manual acupuncture (Jiang et al, 2019) has been explored. However, to date, no study has addressed the combination of donepezil and EE for cognitive impairments in experimentally neurodegenerative status.…”

Section: Ee Increases the Expression Of Neurotrophic Factors And Othe...mentioning

confidence: 99%

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Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats

Gholami

Negah

Rajabian

et al. 2021

Preprint

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Alzheimer's disease (AD) is progressive neurodegeneration known as the most common cause of dementia, and it is the sixth leading cause of death in older people. Given the promising data on the additive effect of combination therapy with donepezil (Aricept), an acetylcholinesterase inhibitor (AChEI), and regarding the similar neuronal mechanisms through them donepezil and environmental enrichment (EE) exert their enhancing effects on cognition; we asked whether simultaneous treatment with two paradigms in amyloid-beta-induced AD rats may lead to greater cognitive improvements than either treatment individually. AD was induced by intrahippocampal injection of amyloid-beta (1-42, 6 µg), and donepezil was orally administrated (4 mg/kg) for 21 days. Environmental enrichment consisted of housing animals in large cages (50× 50× 50 cm) containing a running wheel and differently shaped objects for 21 days. Spatial learning and memory were assessed in the Morris water maze (MWM) and Real-time PCR was performed to assess the expression of brain-derived neurotrophic factor (BDNF) and M1 muscarinic acetylcholine receptor (AchM1R) within the hippocampus. Spatial memory was impaired in AD animals, and while neither pretreatment with donepezil nor EE alone could significantly restore spatial memory scores in AD rats, combination therapy was effective. BDNF expression was suppressed in AD rats and pretreatment with donepezil plus EE could increase it to the saline levels. The data suggest that a cholinesterase inhibitor and cognitive stimulation can be used effectively in combination to improve cognitive loss in an AD rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Ee Increases the Expression Of Neurotrophic Factors And Othe...mentioning

confidence: 99%

Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats

Gholami

Negah

Rajabian

et al. 2021

Preprint

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“…Nazifi M et al showed that piperine significantly ameliorated cognitive deficits by attenuating oxidative status compared to AD-or AD-Tween-treated groups [108]. Piperine at various doses of 5, 10, and 20 mg/kg significantly improved memory impairment and neurodegeneration in the hippocampus, partly associated with the decrease in lipid peroxidation and the acetylcholinesterase enzyme [109].…”

Section: Moas Of Ingredientsmentioning

confidence: 99%

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action

et al. 2022

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Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that currently has reached epidemic proportions among elderly populations around the world. In China, available traditional Chinese medicines (TCMs) that organically combine functional foods with medicinal values are named “Medicine Food Homology (MFH)”. In this review, we focused on MFH varieties for their traditional functional features, substance bases, clinical uses, and mechanisms of action (MOAs) for AD prevention and treatment. We consider the antiAD active constituents from MFH species, their effects on in vitro/in vivo AD models, and their drug targets and signal pathways by summing up the literature via a systematic electronic search (SciFinder, PubMed, and Web of Science). In this paper, several MFH plant sources are discussed in detail from in vitro/in vivo models and methods, to MOAs. We found that most of the MFH varieties exert neuroprotective effects and ameliorate cognitive impairments by inhibiting neuropathological signs (Aβ-induced toxicity, amyloid precursor protein, and phosphorylated Tau immunoreactivity), including anti-inflammation, antioxidative stress, antiautophagy, and antiapoptosis, etc. Indeed, some MFH substances and their related phytochemicals have a broad spectrum of activities, so they are superior to simple single-target drugs in treating chronic diseases. This review can provide significant guidance for people’s healthy lifestyles and drug development for AD prevention and treatment.

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“…Oxidative stress plays a vital role in the pathogenesis of AD and subsequent cognitive impairment. A recent study used intracerebroventricular (ICV) injection of streptozotocin (STZ) for AD modeling in rats by inducing severe oxidative stress and impairing hippocampal neurotransmission [ 37 ]. In their model, a low dose of PIP (2.5 mg/kg/day for 4 weeks) improved the memory task and long-term potentiation in animals.…”

Section: Pip In Neurological and Psychiatric Diseasesmentioning

confidence: 99%

Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases

et al. 2022

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Piperine (PIP) is an active alkaloid of black and long peppers. An increasing amount of evidence is suggesting that PIP and its metabolite’s could be a potential therapeutic to intervene different disease conditions including chronic inflammation, cardiac and hepatic diseases, neurodegenerative diseases, and cancer. In addition, the omnipresence of PIP in food and beverages made this compound an important investigational material. It has now become essential to understand PIP pharmacology and toxicology to determine its merits and demerits, especially its effect on the central nervous system (CNS). Although several earlier reports documented that PIP has poor pharmacokinetic properties, such as absorption, bioavailability, and blood–brain barrier permeability. However, its interaction with metabolic enzyme cytochrome P450 superfamily and competitive hydrophobic interaction at Monoamine oxide B (MAO-B) active site have made PIP both a xenobiotics bioenhancer and a potential MAO-B inhibitor. Moreover, recent advancements in pharmaceutical technology have overcome several of PIP’s limitations, including bioavailability and blood–brain barrier permeability, even at low doses. Contrarily, the structure activity relationship (SAR) study of PIP suggesting that its several metabolites are reactive and plausibly responsible for acute toxicity or have pharmacological potentiality. Considering the importance of PIP and its metabolites as an emerging drug target, this study aims to combine the current knowledge of PIP pharmacology and biochemistry with neurodegenerative and neurological disease therapy.

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The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease

Cited by 23 publications

References 38 publications

Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats

Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action

Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases

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