The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer

Abstract

A pivotal cause of death in the modern world, cancer is an insidious pathology that should be diagnosed at an early stage for successful treatment. Development of therapeutic interventions with minimal invasiveness and high efficacy that can discriminate between tumor and normal cells is of particular interest to the clinical science, as they can enhance patient survival. Nanoparticles are an invaluable asset that can be adopted for development of such diagnostic and therapeutic modalities, since they come in very small sizes with modifiable surface, are highly safe and stable, and can be synthesized in a controlled fashion. To date, different nanoparticles have been incorporated into numerous modalities such as tumor‐targeted therapy, thermal therapy, chemotherapy, and radiotherapy. This review article seeks to deliver a brief account of recent advances in research and application of nanoparticles in hyperthermia‐based cancer therapies. The most recent investigations are summarized to highlight the latest advances in the development of combined thermo‐chemo‐radiotherapy, along with the challenges associated with the application of nanoparticles in cancer therapy.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

Meta‐analysis of the impact of laser interstitial hyperthermia on wound healing complications in brain tumors

“…Laser interstitial hyperthermia therapy has shown great potential as a viable treatment option for patients who are prone to or currently experiencing wound complications resulting from previous treatments, based on various research studies. The cumulative evidence indicates that patients who have experienced previous wound complications or are at an elevated risk of impaired wound healing or wound dehiscence may avoid further worse complications by undergoing LITT 2,7,9,11,24–31 . Several studies have shown that patients undergoing LITT after experiencing previous complications have significantly fewer wound complications (1%–10%) than other treatment options 7,10,11,15–17 .…”

“…The cumulative evidence indicates that patients who have experienced previous wound complications or are at an elevated risk of impaired wound healing or wound dehiscence may avoid further worse complications by undergoing LITT. 2 , 7 , 9 , 11 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 Several studies have shown that patients undergoing LITT after experiencing previous complications have significantly fewer wound complications (1%–10%) than other treatment options. 7 , 10 , 11 , 15 , 16 , 17 While a few individuals reported only a few instances of wound complications following LITT, others stated that there were no reported occurrences of wound complications at all.…”

Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment

“… 27–30 Clinical evidence has consistently demonstrated that combining hyperthermia with chemotherapy effectively enhances local tumor control rates and prolongs patient survival. 31 Xia et al synthesized photo-responsive gold nanoparticles (AuNPs), which exhibited laser-induced accumulation towards the tumor and generated photothermal effects at the tumor site. 32 In vivo experiments conducted on 4T1 tumor-bearing mice demonstrated that laser-induced thermal effects significantly promoted local blood vessel expansion within the tumor area, thereby effectively enhancing the enrichment of chemotherapeutic drugs in the tumor tissue.…”

Persian perspectives: Special issue on nanomedicine and nanobiotechnology in Iran

“…The next topic is combined thermo-and chemo-radiotherapy of cancer (Shirvalilou et al, 2023). At first, (magnetic) hyperthermia was used as a standalone treatment, but more recently it is applied to support more conventional treatments such as chemotherapy and radiation therapy.…”