The gamma camera as an absolute measurement device: Determination of glomerular filtration rate in 99mTc-DTPA renography using a dual head gamma camera

Carlsen, Ove

doi:10.1097/00006231-200410000-00006

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…99m Tc-DTPA renal dynamic imaging (modified Gate’s method) was measured by Millennium TMMPR SPECT using the General Electric Medical System. 99m Tc-DTPA renal imaging showed good agreement with plasma clearance of 51Cr EDTA 13. The 99m Tc-DTPA renal dynamic imaging method used was as previously described 8.…”

Section: Methodsmentioning

confidence: 82%

Variability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease

Liu

Cheng²,

Shi³

et al. 2012

CIA

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BackgroundChronic kidney disease (CKD) is recognized worldwide as a public health problem, and its prevalence increases as the population ages. However, the applicability of formulas for estimating the glomerular filtration rate (GFR) based on serum creatinine (SC) levels in elderly Chinese patients with CKD is limited.Materials and methodsBased on values obtained with the technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA) renal dynamic imaging method, 319 elderly Chinese patients with CKD were enrolled in this study. Serum creatinine was determined by the enzymatic method. The GFR was estimated using the Cockroft–Gault (CG) equation, the Modification of Diet in Renal Disease (MDRD) equations, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Jelliffe-1973 equation, and the Hull equation.ResultsThe median of difference ranged from −0.3–4.3 mL/min/1.73 m2. The interquartile range (IQR) of differences ranged from 13.9–17.6 mL/min/1.73 m2. Accuracy with a deviation less than 15% ranged from 27.6%–32.9%. Accuracy with a deviation less than 30% ranged from 53.6%–57.7%. Accuracy with a deviation less than 50% ranged from 74.9%–81.5%. None of the equations had accuracy up to the 70% level with a deviation less than 30% from the standard glomerular filtration rate (sGFR). Bland–Altman analysis demonstrated that the mean difference ranged from −3.0–2.4 mL/min/1.73 m2. However, the agreement limits of all the equations, except the CG equation, exceeded the prior acceptable tolerances defined as 60 mL/min/1.73 m2. When the overall performance and accuracy were compared in different stages of CKD, GFR estimated using the CG equation showed promising results.ConclusionsOur study indicated that none of these equations were suitable for estimating GFR in the elderly Chinese population investigated. At present, based on overall performance, as well as performance in different CKD stages, the CG equation may be the most accurate for estimating GFR in elderly Chinese patients with CKD.

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Section: Methodsmentioning

confidence: 82%

Variability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease

Liu

Cheng²,

Shi³

et al. 2012

CIA

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“…(8,9) Chronic obstructed kidney with renographic GFR < 10 mL/min/1.73 m 2 is widely accepted as nonsalvageable. (6,10) Meanwhile, the threshold of differential function at which irreversible loss of renal function should be considered is usually accepted as < 15%-20%.…”

Section: Introductionmentioning

confidence: 99%

Excretory urography and renal scintigraphy for chronic obstructed kidney: does nonopacity mean nonsalvageability?

Klaipetch¹,

Namwongprom²,

Ekmahachai³

et al. 2013

smedj

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RESULTSThe results of IVU and renal scintigraphy findings for 34 (75.6%) nonopacified kidneys matched, representing nonsalvageable kidneys. Sensitivity and specificity of differential renal function were 76% and 100%, respectively, when the cutoff point for non-function was set at < 15%. Sensitivity and specificity were 97% and 82%, respectively, when the cutoff point was < 20%. There was no significant difference between renal scintigraphy findings and IVU with 2-hour and > 2-hour delayed films (p = 0.96).CONCLUSION Although most nonopacified kidneys on IVU were nonsalvageable, a quarter of them were found to be salvageable on renal scintigraphy. Besides split GFR, differential function at cutoff point < 15% could be used to determine non-function of a chronic obstructed kidney when the contralateral kidney is normal. Delayed filming beyond two hours appears unnecessary in ensuring non-excretion on IVU.

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“…There were random errors in both cases due to the assessment of attenuation Technique for analysis of geometric mean renography Fleming 707 thickness from lateral measurements. In principle, errors for the geometric mean technique should be less than this if transmission measurements were used to determine attenuation correction factors [14]. This study has not been able to assess the accuracy of either method, as the true value of renal uptake is not known.…”

Section: Discussionmentioning

confidence: 93%

“…It is of note that while this seems intuitively a reasonable assumption, the errors involved have never been rigorously evaluated. However, total renal uptake from geometric mean measurements in renography with 99m Tc-diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) has been used to calculate glomerular filtration rate [14]. The values obtained were shown to correlate well with blood sample measurements.…”

Section: Introductionmentioning

confidence: 99%

A technique for analysis of geometric mean renography

Fleming¹

2006

Nuclear Medicine Communications

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The gamma camera as an absolute measurement device: Determination of glomerular filtration rate in 99mTc-DTPA renography using a dual head gamma camera

Abstract: Since the recording of the renal count rates in the anterior and posterior views permits an accurate determination of the split renal function, the GCM yields reliable estimates also of the single kidney GFR.

Cited by 17 publications

References 10 publications

Variability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease

Variability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease

Excretory urography and renal scintigraphy for chronic obstructed kidney: does nonopacity mean nonsalvageability?

A technique for analysis of geometric mean renography

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