The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial

Abstract

Background: the establishment of periodontitis is regulated by the primary etiological factor and several individual conditions including the immune response mechanism of the host and individual genetic factors. It results when the oral homeostasis is interrupted, and biological reactions favor the development and progression of periodontal tissues damage. Different strategies have been explored for reinforcing the therapeutic effect of non-surgical periodontal treatment of periodontal tissue damage. Gaseous ozone therapy has been recognized as a promising antiseptic adjuvant, because of its immunostimulating, antimicrobial, antihypoxic, and biosynthetic effects. Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote the tissue healing response. Methods: to test this hypothesis, we conducted a prospective randomized study comparing non-surgical periodontal treatment plus gaseous ozone therapy to standard therapy. A total of 90 healthy individuals with moderate or severe generalized periodontitis were involved in the study. The trial was conducted from September 2019 to October 2020. Forty-five patients were randomized to receive scaling and root-planning (SRP) used as conventional non-surgical periodontal therapy plus gaseous ozone therapy (GROUP A); forty-five were allocated to standard treatment (GROUP B). The endpoint was defined as the periodontal response rate after the application of the ozone therapy at 3 months and 6 months, defined as no longer meeting the criteria for active periodontitis. Statistical analysis was performed employing SPSS v.18 Chicago: SPSS Inc. Results: periodontal parameters differed significantly between patients treated with the two distinct procedures at 3 months (p ≤ 0.005); a statistically significant difference between groups was observed from baseline in the CAL (p ≤ 0.0001), PPD (p ≤ 0.0001) and BOP (p ≤ 0.0001) scores. Conclusions: The present study suggests that SRP combined with ozone therapy in the treatment of periodontitis revealed an improved outcome than SRP alone.

Customized Minimally Invasive Protocols for the Clinical and Microbiological Management of the Oral Microbiota

“…It exerts its antiseptic and antibacterial action, reducing the incidence of mucositis and peri-implantitis, periodontal disease, lesions to the mucous membranes of the oral cavity, and both surgical and endodontic post-operative edema [8,9]. Ozone, by its division into three oxygen molecules, has the ability to penetrate inside the DNA and RNA of bacteria and viruses and destroy their structure and is a guaranteed way of reducing healing times by accelerating the healing action.…”

Antispike Immunoglobulin-G (IgG) Titer Response of SARS-CoV-2 mRNA-Vaccine (BNT162b2): A Monitoring Study on Healthcare Workers

“…In fact, almost all organisms in human microbiome/virome communities are ‘pathobionts’, namely they are able to change their gene pool to become pathogenic organisms under conditions of unbalance and immunosuppression [ 92 ]. It is also possible that, after becoming infected, SARS-CoV-2 persists in certain parts of the body or tissues in some persons, causing chronic symptoms [ 93 , 94 , 95 ].…”

Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

“…To this end, three different approaches are adopted: (1) RNA detection test through nucleic acid amplifications using the RT-PCR procedure, (2) antigen tests based on the recognition of a specific surface protein viral antigen, and (3) antibody tests based on the recognition of specific antibodies against SARS-CoV-2. Salivary oral-pharyngeal buffers and serological tests are used for diagnoses; IgM and IgG are measured by using nucleocapsid protein (NP) cross-reactive of another SARSr-CoV Rp3, which is similar for 92% relative to the 2019-nCoV [ 127 , 128 , 129 ].…”