The gene expression and proteomic profiling of Acanthamoeba isolates

Sharma, Chayan; Khurana, Sumeeta; Bhatia, Alka; Arora, Amit; Gupta, Amit

doi:10.1016/j.exppara.2023.108630

Cited by 2 publications

(1 citation statement)

References 60 publications

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“…Acanthamoeba can also produce phospholipases that disrupt the host cell plasma membrane. This results in the loss of cellular integrity, followed by lysis [ 99 , 100 ]. Neuraminidase can target sialic acid in the corneal epithelium, causing damage to the epithelial cells and facilitating Acanthamoeba colonization [ 101 , 102 ].…”

Section: Pathogenesismentioning

confidence: 99%

Epidemiology of and Genetic Factors Associated with Acanthamoeba Keratitis

Ilyas,

Stapleton,

Willcox

et al. 2024

Pathogens

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Acanthamoeba keratitis (AK) is a severe, rare protozoal infection of the cornea. Acanthamoeba can survive in diverse habitats and at extreme temperatures. AK is mostly seen in contact lens wearers whose lenses have become contaminated or who have a history of water exposure, and in those without contact lens wear who have experienced recent eye trauma involving contaminated soil or water. Infection usually results in severe eye pain, photophobia, inflammation, and corneal epithelial defects. The pathophysiology of this infection is multifactorial, including the production of cytotoxic proteases by Acanthamoeba that degrades the corneal epithelial basement membrane and induces the death of ocular surface cells, resulting in degradation of the collagen-rich corneal stroma. AK can be prevented by avoiding risk factors, which includes avoiding water contact, such as swimming or showering in contact lenses, and wearing protective goggles when working on the land. AK is mostly treated with an antimicrobial therapy of biguanides alone or in combination with diaminidines, although the commercial availability of these medicines is variable. Other than anti-amoeba therapies, targeting host immune pathways in Acanthamoeba disease may lead to the development of vaccines or antibody therapeutics which could transform the management of AK.

show abstract

Section: Pathogenesismentioning

confidence: 99%

Epidemiology of and Genetic Factors Associated with Acanthamoeba Keratitis

Ilyas,

Stapleton,

Willcox

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

Epidemiology and Genetic Factors Associated with <em>Acanthamoeba</em> Keratitis

Ilyas,

Stapleton,

Willcox

et al. 2023

Preprint

View full text Add to dashboard Cite

Acanthamoeba keratitis (AK) is a severe, rare protozoal infection of the cornea. Acanthamoeba can survive in diverse habitats and at extreme temperatures. AK is mostly seen in contact lens wearers, whose lenses have become contaminated, or a history of water exposure, and in those without contact lens wear, who have experienced recent eye trauma involving contaminated soil or water. Infection usually results in severe eye pain, photophobia, inflammation, and corneal epithelial defects. The pathophysiology of this infection is multifactorial, including the production of cytotoxic proteases by Acanthamoeba that degrades the corneal epithelial basement membrane and induce the death of ocular surface cells, resulting in degradation of the collagen-rich corneal stroma. AK can be prevented by avoiding the risk factors, which include avoiding water contact such as swimming or showering in contact lenses, and wearing protective goggles when working on the land. AK is mostly treated with an antimicrobial therapy of biguanides alone or in combination with diaminidines, although the commercial availability of these medicines is variable. Other than anti-amoeba therapies, targeting host immune pathways in Acanthamoeba disease may lead to the development of vaccines or antibody therapeutics which could transform the management of AK.

show abstract

The gene expression and proteomic profiling of Acanthamoeba isolates

Cited by 2 publications

References 60 publications

Epidemiology of and Genetic Factors Associated with Acanthamoeba Keratitis

Epidemiology of and Genetic Factors Associated with Acanthamoeba Keratitis

Epidemiology and Genetic Factors Associated with <em>Acanthamoeba</em> Keratitis

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