The Gene for Human Carboxypeptidase U (CPU)— A Proposed Novel Regulator of Plasminogen Activation— Maps to 13q14.11

Curiouser and curiouser: Recent advances in measurement of thrombin-activatable fibrinolysis inhibitor (TAFI) and in understanding its molecular genetics, gene regulation, and biological roles

“…Amino-terminal protein sequence analysis of TAFI and thrombin cleavage products of TAFI [9] revealed that this protein is identical to plasma procarboxypeptidase B, which had been described by Eaton and coworkers in 1991 [8]. Amino acid sequence analyses of purified proCPU and proCPR ultimately revealed that these proteins are also identical to TAFI/plasma procarboxypeptidase B [10,11].…”

Genomic-scale analysis of gene expression profiles in TNF-α treated human umbilical vein endothelial cells

“…We found two prothombotic-related genes and they are both up-regulated only after TNF-a stimulation for 16 h. One is Alpha-2-plasmin inhibitor, which is the most rapidly acting and potent plasmin inhibitor and is important in fibrinolysis [33]; another is Carboxypeptidase B2 (plasma), which functions as a thombin-activable fibrinolysis inhibitor [34]. When ECs are activated, the circulating blood tends to be more viscous and forms clots at the inflammatory sites.…”

Development of a Genotype 325–Specific proCPU/TAFI ELISA

“…2 On activation of proCPU (Phe 1 12 The human proCPU gene is located on chromosome 13q14.11. 13 The gene contains 11 exons and spans approximately 48 kb of genomic DNA. 14 The proCPU promotor lacks a consensus TATA sequence; transcription of the proCPU gene can be initiated from multiple sites and is liver specific.…”