The genetic toxicology of hydroxylamines

Marfey, Peter S.; Robinson, Eleanor M.

doi:10.1016/0165-1110(81)90023-3

Cited by 32 publications

(18 citation statements)

References 207 publications

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“…free radicals participate in the oxidation of deoxyribose moiety, followed by hydrolytic cleavage of the sugar phosphate backbone [38]. The more pronounced nuclease activity of these adducts in the presence of oxidant is due to increased production of hydroxyl radicals.…”

Section: 7mentioning

confidence: 99%

Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard–soft NS donor ligand

Raman¹,

Jeyamurugan²

2009

Journal of Coordination Chemistry

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Knoevenagel condensate-based Schiff base ligands (L) containing N and S donor sites have been designed and synthesized [L ¼ 3-cinnamalideneacetylacetonethiosemicarbazone (CAT)/ 3-cinnamalideneacetylacetoneethylthiosemicarbazone (CAET)/3-cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)]. They afford complexes of the type [ML] [M ¼ Cu(II) and Zn(II)]. Both the ligands and their complexes were characterized by analytical and spectral data. Intercalative binding of these complexes with DNA has been investigated by electronic absorption spectroscopy, viscosity measurements, cyclic voltammetry, and differential pulse voltammetry. Electrophoretic study of the complexes indicates that they efficiently cleave supercoiled pUC19 DNA in the presence of hydrogen peroxide.

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Section: 7mentioning

confidence: 99%

Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard–soft NS donor ligand

Raman¹,

Jeyamurugan²

2009

Journal of Coordination Chemistry

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“…The N 4 -hydroxy derivative of cytosine is a product of the reaction of cytosine with a potent mutagen-hydroxylamine (NH 2 OH) (1). N 4 -hydroxycytosine (OH 4 C) †, created in this reaction, is able to base-pair either as cytosine or as uracil.…”

Section: Introductionmentioning

confidence: 99%

Photochemical syn–anti Isomerization Reaction in N4-Hydroxycytosine. An Experimental Matrix Isolation and Theoretical Study

Lapiński

Nowak

Adamowicz

2001

Photochem Photobiol

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Infrared spectra of N4-hydroxycytosine isolated in argon and nitrogen low-temperature matrixes are reported. The compound was found to adopt the syn structure of the imino-oxo tautomeric form exclusively. A photoreaction (lambda > 250 nm) converting this form into the anti isomer was observed. The reaction is reversible and leads to a photostationary point. The initial infrared spectrum and the spectrum of the photoproduct were assigned to the syn and anti isomers, respectively. This assignment is based on a close agreement between the experimental spectra and the spectra theoretically simulated at the DFT(B3LYP)/6-31++G** level of theory.

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“…Treatment performed on the seeds, with doses of up to 3M, resulted in mutations and chromosome damage. High concentrations of hydroxylamine have been used to inactivate and mutate a number of viruses (6,7). More relevant to the present study were the reports of Kao and Puck (8) and Somers and Hsu (9).…”

Section: Discussionmentioning

confidence: 90%

“…Hydroxylamine is a strong nucleophile and free radicalgenerating reagent and thus might be expected to interact with nucleic acids as well as proteins (6). These interactions account for its cytotoxic action and mutagenic action in several cell systems.…”

Section: Discussionmentioning

confidence: 99%

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Mutagenic Potential of Hydroxylamine Hydrochloride (WR 740) in the Mouse Lymphoma Forward Mutation Assay

Harbell¹,

Korte²

1988

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The genetic toxicology of hydroxylamines

Cited by 32 publications

References 207 publications

Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard–soft NS donor ligand

Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard–soft NS donor ligand

Photochemical syn–anti Isomerization Reaction in N4-Hydroxycytosine. An Experimental Matrix Isolation and Theoretical Study

Mutagenic Potential of Hydroxylamine Hydrochloride (WR 740) in the Mouse Lymphoma Forward Mutation Assay

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