The genus Calea L.: A review of isolated compounds and biological activities

Amaral, Patrícia de Aguiar; Costa, Franciely Vanessa; Antunes, Altamir Rocha; Kautz, Jacqueline; Citadini-Zanette, Vanilde; Dévéhat, Françoise Lohézic-Le; Barlow, James W.; DalBó, Silvia

doi:10.5897/jmpr2017.6412

J. Med. Plants Res.

2017

DOI: 10.5897/jmpr2017.6412

|View full text |Cite

The genus Calea L.: A review of isolated compounds and biological activities

Patrícia de Aguiar Amaral¹,

Franciely Vanessa Costa²,

Altamir Rocha Antunes³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Synthesis and anti-leishmanial activities of uniflorol analogues

da Silva Cardoso,

Niero,

Frizon

et al. 2024

Med Chem Res

View full text Add to dashboard Cite

Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and synthetic derivatives. Among these, we selected the natural product uniflorol, a 4-chromanone with an α,β-unsaturated ketone side chain, as a lead compound due to its reported anti-leishmanial properties. We designed and synthesised four series of novel compounds, varying the substitution patterns around the benzopyran core, and evaluated the compounds for anti-leishmanial activity against amastigotes of L. infantum. We prepared and characterised 24 novel compounds; upon screening, 12 compounds demonstrated activity values of <50 μM, with the most potent compound, 16d, having an IC50 of 7.29 μM. Activity was favoured in compounds bearing a phenylalkenyl motif, such as cinnamyl, styryl or a more lipophilic extension, and amide analogues retained activity. Uniflorol analogues display promise as novel architectures towards the development of potential anti-leishmanial agents.

show abstract

Synthesis and anti-leishmanial activities of uniflorol analogues

da Silva Cardoso,

Niero,

Frizon

et al. 2024

Med Chem Res

View full text Add to dashboard Cite

show abstract

Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis

Grafakou

Barda

Karikas

et al. 2021

Bioorganic Chemistry

View full text Add to dashboard Cite

Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents

Castro

Cruz

Amaral

et al. 2020

Heliyon

View full text Add to dashboard Cite

Within this work, we describe the design and synthesis of a range of novel chromanones and quinolinones, based on natural products reported to possess anti-leishmanial action. The core heterocycles were obtained either via classical or ionic liquid mediated Kabbe condensation in the case of chromanones, or aqueous Sonogashira based alkynylation followed by acid-catalysed cyclisation in the case of quinolinones. Upon testing in promastigotes, axenic amastigotes and Leishmania-infected macrophages, compound 13c was identified as displaying interesting activity, inhibiting axenic amastigotes and intracellular amastigotes with IC 50 s of 25.3 and 24.6μM respectively.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The genus Calea L.: A review of isolated compounds and biological activities

Cited by 5 publications

References 70 publications

Synthesis and anti-leishmanial activities of uniflorol analogues

Synthesis and anti-leishmanial activities of uniflorol analogues

Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis

Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents

Contact Info

Product

Resources

About