The Genus <i>Neolitsea</i> of Lauraceae: A Phytochemical and Biological Progress

Yuan, Chengfu; Gao, Xiaoli; Su, Guo‐Zhu; Yu, Xuelong; Tu, Pengfei; Chai, Xingyun

doi:10.1002/cbdv.201400084

Cited by 11 publications

(4 citation statements)

References 63 publications

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“…The 3J coupling appears between (H-2) and (H-3) in the COSY spectrum, as well as between the (H-5) and (H-6), confirming the position of the protons in the molecule, in addition to comparison with literature data (Reynolds et al, 1986). Lupeol was isolated from many plants in the Lauraceae such as Neolitsea sericea (Cao et al, 2015), Beilschmiedia glabra (Lenta et al, 2015) and B. erythrophloia (Salleh and Ahmad, 2017). In addition, it was isolated from other families such as Ficus pseudopalma Blanco (Santiago and Mayor, 2014) and Scapium macropodum (Al Muqarrabun et al, 2014).…”

Section: Resultssupporting

confidence: 76%

Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Rosandy

Ishak

Sabri

et al. 2021

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Dehaasia is a member Lauraceae. It is locally known as ‘gajus hutan’ or ‘pekan’. A triterpenoid, lupeol was isolated from the bark of Dehaasia cuneate. The structure of the isolated compound was determined using spectroscopic methods, such as UV–vis, FT-IR, 1D and 2D NMR, and mass spectrometer. The isolated compound was tested against Gram-negative and positive bacteria using agar disc diffusion technique. The results showed that lupeol had a moderate inhibition zone value of 10.0±0.00 mm against Gram-negative Serratia marcescens ATCC 14756 whereas low inhibition which is 7.0±0.00 mm against Escherichia coli ATCC 25922, Vibrio fluvialis ATCC 33809, Bacillus subtilis ATCC 6633, and Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.

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Section: Resultssupporting

confidence: 76%

Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Rosandy

Ishak

Sabri

et al. 2021

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“…In Taiwan, there are 12 Neolitsea species and four of them, including N. acuminatissima , N. daibuensis , N. hiiranensis , and N. parvigemma , are endemic [19]. Recent studies on the diversity of phytochemical structures and bioactivities revealed the application potential of Neolitsea plants in industrial and medical fields [20, 21]. Parts of Neolitsea plants have been used in folk medicine for long periods of time in Asia.…”

Section: Introductionmentioning

confidence: 99%

“…The roots of N. zeylanica have been shown to relieve rheumatic arthralgia [22]. Studies on the chemistry and pharmacology of Neolitsea species have led to the isolation and identification of more than 150 compounds including alkaloids, terpenoids, sterols, steroids and their derivatives, flavonoids, essential oils, and fatty acids with diverse activities [21, 23]. The essential oils of N. pallens exhibited antioxidant and antibacterial activities [24].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of TaiwaneseNeolitseaSpecies on Th1 and Th2 Functionality

Cheng

Lin

Chen

et al. 2017

Journal of Immunology Research

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Neolitsea species, medicinal plants belonging to Lauraceae, contain rich alkaloids, steroids, sesquiterpenoids, and triterpenoids which possess antimicrobial, antioxidant, and anti-inflammatory bioactivities. However, species differences in the immunomodulatory effects and evidence pertaining to the effects of Neolitsea species on adaptive immunity are scarce. This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2. Most of the 29 crude extracts of Neolitsea were not toxic to splenocytes, except N. buisanensis roots. N. aciculata and N. villosa leaf extracts possessed differential immunomodulatory effects on Th1/Th2 balance. N. aciculata var. variabillima and N. hiiranensis leaf extracts attenuated both Th1 and Th2 cytokines while N. konishii dramatically suppressed IFN-γ production. As N. aciculata var. variabillima and N. konishii leaf extracts significantly attenuated Th1 functionality, we further evaluated their effects on CD4 cells under CD3/CD28 stimulation. N. aciculata var. variabillima significantly suppressed IFN-γ, IL-10, and IL-17, demonstrating the broad suppressive effects on T helper cells; N. konishii significantly suppressed IFN-γ and IL-10 production, while the production of IL-17 was not altered. Collectively, these data demonstrated that leaf extracts of Taiwanese Neolitsea species contain phytochemicals with potentials to be developed as selective immunomodulators.

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“…Neolitsea is a genus of evergreen shrubs and small trees belonging to the Laurel family, Lauraceae. Approximately 100 species of the genus are found mainly in tropical regions of Asia [1] and some species are distributed in America [2], Australia and Malaysia [3]. A number of Neolitsea species, such as N. zeylanica [4] and N. aurata [5], are used traditionally for treating various illnesses.…”

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confidence: 99%

Chemical Composition, Antibacterial and α-Glucosidase Inhibitory Activities of the Essential Oils of Neolitsea coccinea (Lauraceae)

Jani

Sirat

Ahmad

et al. 2016

Natural Product Communications

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The chemical composition, antibacterial and α-glucosidase inhibitory activities of the essential oils obtained from hydrodistillation of the fresh stem and leaf of Neolitsea coccinea B. C. Stone are reported for the first time. GC and GC-MS analysis revealed the presence of 42 volatile compounds from the stem and leaf oils, accounting for 84.9% and 90.4%, respectively of the identified components. The principle compounds in the stem oil were δ-cadinene (21.2%), 1-epi-cubenol (11.3%) and cyperotundone (10.7%), while the main compounds in the leaf oil were selin-11-en-4-α-ol (26.8%), bicyclogermacrene (12.6%), γ-eudesmol (7.1%), germacrene D (6.1%) and globulol (5.9%). The leaf oil demonstrated moderate to weak antibacterial activity towards Bacillus subtilis and Staphylococcus aureus with MIC values of 250 μg/mL and 500 μg/mL, respectively, whereas the stem oil possessed weak antibacterial activity against B. subtilis with a MIC value of 500 μg/mL. The stem and leaf oils showed significant α-glucosidase inhibitory activity with IC50 values of 32.2 ± 0.8 μg/mL and 70.9 ± 1.1 μg/mL, respectively.

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The Genus Neolitsea of Lauraceae: A Phytochemical and Biological Progress

Cited by 11 publications

References 63 publications

Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Immunomodulatory Effects of TaiwaneseNeolitseaSpecies on Th1 and Th2 Functionality

Chemical Composition, Antibacterial and α-Glucosidase Inhibitory Activities of the Essential Oils of Neolitsea coccinea (Lauraceae)

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