The geometrical phase transition in non-linear hydrogen bonding systems

Wang, Haijun; Hong, Xiao-Zhong; Ba, Xinwu

doi:10.1016/j.cplett.2005.07.089

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…This result can reduce the form of the single component HB system as reported in our previous letter. 13 In addition, by changing the corresponding symbols, one can easily check this gelation condition recovers the result proposed by Flory and Stockmayer for polycondensation of A a -B b type. 14,15 When the SGT takes place, one can further consider the free energy corresponding to the sol and gel phases.…”

Section: The Properties Of the System In The Postgel Regimesupporting

confidence: 77%

“…12 Recently, we have considered the SGT in the nonlinear HB liquid system consisting of identical A a D d type molecules (each of them possesses a proton acceptors A and d proton donors D). 13 In this paper we study a modeling system of HB solution consisting of N 1 molecules of A a1 D d1 and N 2 molecules of A h a2 D h d2 types, and the corresponding symbols have the similar interpretations as that in A a D d type. Note that, now the proton acceptor A h and proton donor D h may be identical with A and D or not, then such a system is obviously more complicated than the HB liquid system.…”

Section: Introductionmentioning

confidence: 99%

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Sol−Gel Transition in Nonlinear Hydrogen Bonding Solutions

Wang

Hong

2007

Macromolecules

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Hydrogen bonding (HB) in a mixed nonlinear system consisting of A a 1 D d 1 and Ā a 2 D̄ d 2 types of molecules is studied with the different activities of the groups being taken into account. Under the framework of the mean field theory, the partition function concerned the HB process of the system is given by two different statistical viewpoints. By which the equilibrium free energy of the system in the pregel regime, the law of mass action of HB process and the equilibrium size distribution of the HB clusters are carried out. The sol−gel phase transition is shown to take place in such a HB system with the gelation condition being given, and then the sol and gel free energies in the postgel regime are also obtained. Furthermore, the scaling laws satisfied by the kth moments and the gel fraction near the critical point are obtained for describing this kind of phase transition.

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Section: The Properties Of the System In The Postgel Regimesupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Sol−Gel Transition in Nonlinear Hydrogen Bonding Solutions

Wang

Hong

2007

Macromolecules

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“…Experimental details about this rapidly shifting network are still elusive despite continuous effort in this area. A theoretical scaling description was recently given , for the sol−gel phase transition in water as well as in other solvents satisfying the networking condition of having at least two donor and two acceptor sites per molecule (growth of clusters up to formation of an infinite gel network of hydrogen bonds). Current work shows that long-lived huge (probably netlike) structures are seen by light scattering upon addition of solute into these classes of liquids.…”

Section: Resultsmentioning

confidence: 99%

Large-Scale Supramolecular Structure in Solutions of Low Molar Mass Compounds and Mixtures of Liquids. III. Correlation with Molecular Properties and Interactions

Sedlák

2006

J. Phys. Chem. B

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The presence of a large-scale supramolecular structure is evidenced in a large variety of electrolyte solutions, nonelectrolyte solutions, and mixtures of liquids. This structure comprises submicron-sized domains with different solute concentration from that in the rest of solution. While the first paper of this series [J. Phys. Chem. B 2006, 110 (9), 4329-4338] dealt with a detailed characterization of the supramolecular structure and the second paper [J. Phys. Chem. B 2006, 110 (9), 4339-4345] dealt with the kinetics of the formation of this structure and its long-time stability, the present work contains a detailed classification of systems with respect to the capability of formation of the supramolecular organization. Around 100 different solute-solvent pairs were investigated in total, covering most common inorganic and organic electrolytes, nonionic solid compounds, and a large variety of liquids. The main experimental techniques used were static and dynamic light scattering, which are very effective techniques in observing and characterizing association. Light scattering data were complemented by osmotic pressure data obtained by vapor pressure osmometry, which reflects association on a different principle. The presence and intensity of the supramolecular domain organization was correlated with properties and interactions between constituent molecules and ions. The most plausible explanation of the observed effect of the large-scale supramolecular structure at this stage of our knowledge is that domains form due to directional attractive interactions between solute molecules via hydrogen bond bridges formed by one or several solvent molecules, which are themselves hydrogen bonded.

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“…Later, Wang et al. examine the effect of dehydroevodiamine on scopolamine‐ and Aβ(25–35)‐induced amnesia in mice by using a step‐through passive avoidance test . The authors note that dehydroevodiamine is more potent in improving Aβ(25–35)‐induced amnesia than in improving scopolamine‐induced amnesia when administered before the training trial.…”

Section: Discussionmentioning

confidence: 99%

“…Amiodarone and bepridil inhibit β‐secretase cleavage at therapeutically achievable concentrations in vivo in guinea pigs . Benzofuran‐ and indole‐based inhibitors such as dehydroevodiamine hydrochloride (DHED), posiphen, indomethacin, DP‐155, KMS88009, 2‐methyl‐5‐(3‐{4‐[( S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazolein (MMBO), tadalafil, melatonin, and tubastatin A have been proven to be effective in a transgenic mice model of AD. A few other benzofuran‐ and indole‐based compounds such miyabenol C, indomethacin, 28 , K252a, 35 b – d , tacrine–melatonin hybrid 38 , 39 d , 64 c / 64 d , 68 d , 75 , and 77 have been tested in cellular models.…”

Section: Discussionmentioning

confidence: 99%

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

2018

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Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. The Food and Drug Administration has approved drugs (e.g., rivastigmine, donepezil, galantamine, and memantine) that at best provide marginal benefits, thus emphasizing the urgent need to explore other molecular entities as future drug candidates for AD. Looking at the wide pharmaceutical applications of heterocyclic compounds and particularly those containing benzofuran and indole ring systems, these molecular frameworks have drawn special attention from medicinal chemists for further evaluation in numerous diseases. This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, γ-secretase, β-secretase, tau misfolding, and β-amyloid aggregation.

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The geometrical phase transition in non-linear hydrogen bonding systems

Cited by 11 publications

References 30 publications

Sol−Gel Transition in Nonlinear Hydrogen Bonding Solutions

Sol−Gel Transition in Nonlinear Hydrogen Bonding Solutions

Large-Scale Supramolecular Structure in Solutions of Low Molar Mass Compounds and Mixtures of Liquids. III. Correlation with Molecular Properties and Interactions

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

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