The GerdQ questionnaire and high resolution manometry support the hypothesis that proton pump inhibitor‐responsive oesophageal eosinophilia is a <scp>GERD</scp>‐related phenomenon

Savarino, Edoardo; Tolone, Salvatore; Bartolo, Ottavia; Cassan, Chiara De; Caccaro, Roberta; Galeazzi, Francesca; Nicoletti, Loredana; Salvador, Renato; Martinato, Matteo; Costantini, Mario; Savarino, Vincenzo

doi:10.1111/apt.13718

Cited by 41 publications

(36 citation statements)

References 38 publications

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“…However, Savarino et al . showed that PPI‐REE has more frequently clinical, endoscopic, and manometric features similar to those of GERD patients . Furthermore, Podboy et al .…”

Section: Interaction Between Eoe Gastro‐esophageal Reflux Disease Amentioning

confidence: 95%

“…25,26 However, Savarino et al showed that PPI-REE has more frequently clinical, endoscopic, and manometric features similar to those of GERD patients. 27 Furthermore, Podboy et al have suggested that EoE patients have earlier onset of symptoms (29 versus 38 years), and, using xray barium swallow (which is more sensitive than endoscopy in order to detect a decrease in wall compliance), that they have more frequently long strictures (>8 cm, 51% versus 18% of patients), and a trend toward developing these long segment strictures after 20 years of dysphagia duration (73% versus 30%). 28 Regarding the classical endoscopic features, PPI-REE shows no difference from EoE.…”

Section: Interaction Between Eoe Gastro-esophageal Reflux Disease Amentioning

confidence: 99%

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Eosinophilic esophagitis: latest insights from diagnosis to therapy

Schoepfer

Blanchard

Dawson

et al. 2018

Annals of the New York Academy of Sciences

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Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011. In 2017, new international guidelines were published based on the GRADE methodology. These guidelines provide, among many other topics, insights on the role of proton pump inhibitor-responsive esophageal eosinophilia. Over the last two decades, considerable progress was made by stakeholders regarding the understanding of EoE's pathogenesis, genetic background, natural history, allergy workup, standardization of assessment of disease activity, evaluation of minimally invasive diagnostic tools, and new therapeutic approaches. This brief review provides further insights into latest diagnostic and therapeutic advances.

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“…However, Savarino et al . showed that PPI‐REE has more frequently clinical, endoscopic, and manometric features similar to those of GERD patients . Furthermore, Podboy et al .…”

Section: Interaction Between Eoe Gastro‐esophageal Reflux Disease Amentioning

confidence: 95%

Section: Interaction Between Eoe Gastro-esophageal Reflux Disease Amentioning

confidence: 99%

Eosinophilic esophagitis: latest insights from diagnosis to therapy

Schoepfer

Blanchard

Dawson

et al. 2018

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…1 The authors report that typical features of reflux disease were indistinguishable between GERD and PPI-REE patients, and much more common than in EoE patients. In contrast, previous systematic reviews did not observe major differences between PPI-REE and EoE patients.…”

mentioning

confidence: 97%

“…SIRS, We thank Drs Molina-Infante et al for taking the time to read our paper, 1 and for their comments. 2 The authors criticise our selection of gastro-oesophageal reflux disesase (GERD) patients and therefore the results of our study.…”

mentioning

confidence: 99%