The German Human Biomonitoring Commission

Schulz, Christine; Angerer, Jürgen; Ewers, U.; Kolossa-Gehring, Marike

doi:10.1016/j.ijheh.2007.01.035

Cited by 169 publications

(114 citation statements)

References 35 publications

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“…Its effects on birth outcomes, however, particularly at moderate exposures, are not well understood and in this regard Cd has received far less research attention than its near neighbours in the periodic table, lead and mercury, The placenta is thought to be at least a partial barrier to Cd transfer to the fetus,5, 6 but determination of ratios of Cd in cord blood : maternal blood have left this in doubt (ratios ranging from 0.247 to 1.08,8 with others finding intermediate values9, 10). Studies with moderate maternal blood cadmium levels (B‐Cd; below a suggested reference value of 1 μg/L11) and adjustment for smoking have generally found no associations with birthweight, birth length, head circumference or preterm delivery,8, 12, 13 but other studies have found negative associations particularly with birthweight14, 15, 16 (Table S1). Even where exposure levels are higher and effects could potentially be more evident, again some studies have found no associations with birth outcomes,10, 17 while others have found adverse associations 18.…”

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confidence: 99%

Moderate Prenatal Cadmium Exposure and Adverse Birth Outcomes: a Role for Sex‐Specific Differences?

Taylor

Golding

Emond

2016

Paediatric Perinatal Epid

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Background/AimStudies on the effects of moderate prenatal exposure to cadmium (Cd) on birth outcomes have been contradictory and it has been suggested that effects may be partly masked by sex‐specific effects. Our aim was to examine the association of Cd exposure in a large group of pregnant women with birth outcomes in the whole group of participants and by sex.MethodsPregnant women were enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples for singleton pregnancies with a live birth were analysed for Cd (n = 4191). Data collected on the infants included anthropometric variables and gestational age at delivery. Data were analysed using SPSS v18.ResultsThere were adverse associations of maternal blood Cd level with birthweight (unstandardized B coefficient −62.7 g, 95% CI −107.0, −18.4) and crown–heel length (−0.28 cm, 95% CI −0.48, −0.07) in adjusted regression models. On stratification by sex, maternal blood Cd level was adversely associated with birthweight (−87.1 g, 95% CI −144.8, −29.4), head circumference (−0.22 cm, 95% CI −0.39, −0.04), and crown–heel length (−0.44 cm, 95% CI −0.71, −0.18) in girls but not in boys in adjusted regression models.ConclusionIn these pregnant women with moderate prenatal Cd exposure there evidence of adverse associations with birth anthropometry variables in the whole group. However, there was evidence of associations with anthropometric variables in girls that were not evident in boys. Sex‐specific effects require further investigation in large cohorts as a possible contributor to the lack of associations generally found in mixed‐sex studies.

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mentioning

confidence: 99%

Moderate Prenatal Cadmium Exposure and Adverse Birth Outcomes: a Role for Sex‐Specific Differences?

Taylor

Golding

Emond

2016

Paediatric Perinatal Epid

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“…To identify possible trends between the 4 groups (control, low-exposed, medium-exposed, high-exposed) the linear trend test was applied. To compare normal-distributed metric Human Biomonitoring Commission [46,47]. The selection of threshold values applied for this study was discussed in our former papers [16,19,48].…”

Section: Methodsmentioning

confidence: 99%

Signs and symptoms of mercury-exposed gold miners

Blüml

Bernaudat

Siebert

et al. 2017

Int J Occup Med Environ Health

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“…It is aimed to aid in data interpretation by statistical derivation of reference values and toxicological-epidemiological derivation of HBM-values I and II (see below). Additionally, the HBM-Commission was asked to make recommendations concerning chemical exposures to the public health services, individuals, the general population and policy makers [24]. Recommendations of this kind are needed to ensure well maintained health status of the population, to control the success of chemicals policy and to further develop it.…”

Section: The Human Biomonitoring Commissionmentioning

confidence: 99%