The German ISS-experiment Cellular Responses to Radiation in Space (CERASP): The effects of single and combined space flight conditions on mammalian cells

Hellweg, Christine E.; Thelen, Melanie; Arenz, Andrea; Baumstark‐Khan, Christa

doi:10.1016/j.asr.2006.11.015

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Unfortunately, we could not find evidence indicating that the above biological experiments were intensively conducted to obtain basic information on the cellular response to radiation applied under the microgravity environment. Later, the importance of such a study to be performed at ISS was pointed out by a German group in 2007 (Hellweg et al, 2007). This group previously determined that densely IR such as accelerated ion particles have a stronger potential for activating NF-κ B dependent gene expression than sparsely IR such as X-rays.…”

Section: Implication Obtained From the National Esa Soyuz Missionsmentioning

confidence: 97%

Are biological effects of space radiation really altered under the microgravity environment?

Yatagai

Ishioka

2014

Life Sciences in Space Research

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Section: Implication Obtained From the National Esa Soyuz Missionsmentioning

confidence: 97%

Are biological effects of space radiation really altered under the microgravity environment?

Yatagai

Ishioka

2014

Life Sciences in Space Research

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“…The space environment is known to be chronically in ammatory as astronauts in previous studies have reported increased in ammation markers for the ight duration [14][15][16] . In the NASA Twins Study, both career astronauts had increased mutational burden in epigenetic regulators such as DNMT3A and TET2 compared to prostate cancer patient controls.…”

Section: Astronautsmentioning

confidence: 99%

Genome and Clonal Hematopoiesis Stability Contrasts with Immune, cfDNA, mitochondrial, and telomere length changes to Short Duration Spaceflight

Medina

Narayanan

Sienkiewicz

et al. 2023

Preprint

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The I4 mission, the first all-civilian orbital flight mission, investigated the physiological effects of short duration spaceflight through a multi-omic approach. We analyzed telomere length, clonal hematopoiesis of indeterminate potential (CHIP), whole genome stability, cell-free DNA (cfDNA) cell lysis, and immune cell gene expression. Our results revealed telomere length dynamics similar to those observed in the NASA Twins Study and in astronauts spending 6 months on the ISS, with lengthening in space and shortening upon return to Earth. Our cell-type of origin analysis of cfDNA fragments revealed an increased presence of innate and adaptive immune cell signatures that persisted over a month after return to earth. No significant relationship between spaceflight and CHIP-related or whole genome abnormalities were observed. Longitudinal mitochondrial, ribosomal and immune function gene expression changes occurred across both adaptive and innate immune cells, suggesting adaptations to the space environment can extend months after return from spaceflight and alter immune function. Our findings provide valuable insights into the physiological consequences of short duration spaceflight and will serve as a reference point for future space tourism, low Earth-orbit (LEO) missions, and deep-space exploration.

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“…The future research on Pm is expected to bring us into the outer space. Promethium is used as a prototype radiation source in attempts to simulate space conditions on Earth (Hellweg et al, 2007). Since cosmic radiation is identified as the most hazardous for the health of crew participating in long-term interplanetary missions (e.g., Mars), 147 Pm radiation is used in biological experiments aimed at determination of the allowed irradiation dose range of human embryonic kidney (HEK) cells survival (Hellweg et al, 2008).…”

Section: Conclusion Outlook and Outer Spacementioning

confidence: 99%

Promethium: To Strive, to Seek, to Find and Not to Yield

Elkina

Kurushkin

2020

Front. Chem.

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Promethium (Pm), element #61, got its name from the Greek Titan Prometheus, who stole fire from Zeus and passed it to people. The only element in the lanthanide series of the periodic table with no stable isotopes, Pm has found an impressive number of applications since its announcement in 1947 after World War II. Despite promethium having 38 known isotopes, 147 Pm is by far the most utilized and useful one. Promethium is used in long-life atomic batteries for satellites or space probes, satellite-to-submarine laser communication systems, "cosmic clocks" for the measurement of cosmic rays lifetime, monitoring of the changes in water content of citrus leaves caused by wetting and drying cycles in the soil, radiotherapy, and even for prevention of dandruff, to name but a few applications. During the Moon expeditions, Pm was used to illuminate instruments in the Apollo landing modules; currently it is used during preparations for long-term interplanetary missions (e.g., Mars) to simulate space conditions on Earth. This mini review offers a comprehensive illustration of promethium's history, synthesis techniques, properties, and its major applications in science, technology, and everyday life.

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The German ISS-experiment Cellular Responses to Radiation in Space (CERASP): The effects of single and combined space flight conditions on mammalian cells

Cited by 8 publications

References 20 publications

Are biological effects of space radiation really altered under the microgravity environment?

Are biological effects of space radiation really altered under the microgravity environment?

Genome and Clonal Hematopoiesis Stability Contrasts with Immune, cfDNA, mitochondrial, and telomere length changes to Short Duration Spaceflight

Promethium: To Strive, to Seek, to Find and Not to Yield

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