The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats

Chávez-Morales, R.M.; Jaramillo-Juárez, Fernando; Rodríguez-Vázquez, María Luisa; Martínez-Saldaña, María Consolación; Rio, Francisco A. Posadas del; Garfias-López, J.A.

doi:10.1016/j.etp.2017.04.003

Cited by 17 publications

(7 citation statements)

References 52 publications

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“…Remarkably, the extract of G. biloba leaves (EGb) attenuates the neuronal damage in animals (Li et al, 2017;Zhou et al, 2017) and in vitro (Yang et al, 2018). The chemical constituents of EGb are evaluated as follows: 22%-27% of flavone glycosides, 2.8%-3.4% of Ginkgolide A, B, and C, 2.6%-3.2% of bilobalide, and less than 5 ppm of ginkgolic acid (Chávez-Morales et al, 2017). Modern pharmacological studies have shown that the combination of extract of G. biloba and donepezil may be beneficial in the treatment of AD inratand mice (Stein etal., 2015;Zhangetal., 2019).…”

Section: Introductionmentioning

confidence: 99%

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

Liu

Guo³

2020

Front. Pharmacol.

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Alzheimer's disease (AD) is a common neurodegenerative disease, mainly manifested by cognitive dysfunction. It seriously reduces the quality of life, and there is no ideal treatment strategy in clinical practice. Clinical studies on the treatment of AD with Ginkgo biloba L. leaf extract (EGb) have been reported since 1980s, and many clinical studies have been carried out during the following 30 years. However, the benefits of EGb on the treatment of AD are still controversial. In this review, we collected the clinical trial reports of EGb on cognitive function from Pubmed, Elsevier, Europe PMC, and other database since the 1980s. Through analysis and comparison, we consider that EGb may be able to improve the cognitive function in patients who suffered from mild dementia during long-term administration (more than 24 weeks) and appropriate dosage (240 mg per day). The main evidences and existing problems of the negative and positive experimental results were summarized.

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Section: Introductionmentioning

confidence: 99%

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

Liu

Guo³

2020

Front. Pharmacol.

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“…Moreover it has benefi cial effects in the treatment of neurological, cardiovascular, age-related and various diseases (28,29). Thus, the aim of this study was to investigate the therapeutic effect of EGb761 on cellphone-EMRinduced testicular damage and impairment of sperm production in adult male rats.…”

Section: Introductionmentioning

confidence: 99%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0.96 W/kg) for six weeks (4 hrs/day). Egb761 (100 mg/kg/day) was also added to the treatment. Testes, epididymal semen and blood plasma were used for analysis. RESULTS: Exposure to cellular phone radiation resulted in a signifi cant impairment in testicular morphometry and histological structure, reduction of total and motile sperm numbers and plasma testosterone level. Egb761 administration improved testicular damage and led to a marked increase in plasma testosterone levels and total and motile sperm numbers. CONCLUSION: Male reproductive system is susceptible to cellphone radiation. Cellphone waves induce toxic effects in testicular tissues, impair spermatogenesis and cause an imbalance in testosterone hormone levels. Egb761 ameliorated these toxic effects by reversing testicular tissue damage, restoring normal spermatogenesis and hormone levels. This suggests that Egb761 is a potential therapeutic agent against EMR-induced male reproductive toxicity (Tab. 3, Fig. 6, Ref. 45). Text in PDF www.elis.sk.

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“…The authors believe that this result is due to the inhibition of protein expression by CCl 4 in the liver and the restoring effect of GBLE in this case was expressed as a modulating influence (Chavez‐Morales et al, ). Another experiment of Chavez‐Morales et al () demonstrated that neither of renal functional factors, including urine flux, clearance of inulin, and p‐aminohippurate was influenced by CCl 4 , but it significantly increased proteinuria, MDA level, and induced tubular necrosis more in the inner cortex of the kidneys. GBLE administration significantly alleviated these injuries (Chavez‐Morales et al, ).…”

Section: Chemical Toxicitiesmentioning

confidence: 98%

“…Another experiment of Chavez‐Morales et al () demonstrated that neither of renal functional factors, including urine flux, clearance of inulin, and p‐aminohippurate was influenced by CCl 4 , but it significantly increased proteinuria, MDA level, and induced tubular necrosis more in the inner cortex of the kidneys. GBLE administration significantly alleviated these injuries (Chavez‐Morales et al, ).…”

Section: Chemical Toxicitiesmentioning

confidence: 98%

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Omidkhoda

Razavi

Hosseinzadeh

2019

Phytotherapy Research

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Nowadays in our developing and industrial world, humans' health or even their life is threatened by exposure to poisons. In this situation, detecting a protective compound could be helpful and interesting. In the present article, we collected and reviewed all studies, which have been conducted so far about the protective effects of Ginkgo biloba L. (GB), one of the most ancient medicinal tree species, against toxicities induced by chemical toxic agents, natural toxins, and also radiation. In overall, investigations showed that GB exerts the antioxidant, antiinflammatory, antiapoptotic, and antigenotoxicity effects in different toxicities. There are also some special mechanisms about its protective effects against some specific toxic agents, such as acetylcholine esterase inhibition in the aluminium neurotoxicity or membrane‐bond phosphodiesterase activation in the triethyltin toxicity. Ginkgolide A was the most investigated active ingredient of G. biloba leaf extract as a protective compound against toxicities, which had the similar effects of total extract. A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings.

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The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats

Cited by 17 publications

References 52 publications

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

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