The global need for effective antibiotics—Moving towards concerted action

Cars, Otto; Hedin, A.; Heddini, Andreas

doi:10.1016/j.drup.2011.02.006

Cited by 87 publications

(58 citation statements)

References 8 publications

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“…Antibacterials are essential in the prevention and treatment of bacterial infection which commonly occurs in surgery, organ transplant, cancer chemotherapy, and in veterinary applications [2]. In particular, the emergence of methicillin resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, third-generation cephalosporins resistant Escherichia coli and Klebsiella pneumonia, penicillin resistant Streptococcus pneumoniae, extended spectrum β-lactamase, and carbapenem-resistant Enterobacteriaceae are prominent examples that are both widespread and of great concern [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…A further challenge is that multidrug resistant bacteria are becoming ubiquitous in both developed and developing countries [8,9] and that newly discovered antibacterial agents have limited revolutionary mechanisms of action for clinical use [10]. These issues have motivated new strategies and initiatives launched by the Infectious Diseases Society of America (Policy), Action on Antibiotic Resistance (ReAct) [2,11], and The British Society for Antibiotic Chemotherapy (BSAC) [12] with the purpose of improving research and development of new antibacterial drugs.…”

Section: Introductionmentioning

confidence: 99%

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In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Chen

Jamaludin

Khoo

et al. 2016

Journal of Inorganic Biochemistry

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Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and Cy (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity.All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA).Time kill assays revealed the compounds to exhibit both time-and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophilia, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Chen

Jamaludin

Khoo

et al. 2016

Journal of Inorganic Biochemistry

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“…This concern has been due to the increase in bacterial resistance to antibiotics along with increased incidence of side effects associated with commonly used drugs and the clinical importance given to infections particularly in immunocompromised patients (Cars et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Resistance to antibiotics is a growing concern in the treatment of many bacterial diseases (Cars et al, 2011). Antimicrobial resistance increases morbidity and mortality in patients with infections, while costs to health institutions are greatly increased (Coutinho et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Figueredo¹,

Lucena²,

Tintino³

et al. 2013

Pharmaceutical Biology

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Context: The combination of antibiotics with natural products has demonstrated promising synergistic effects in several therapeutic studies. Objective: The aim of this study was to determine the effect of a combination of an ethanol extract of Myracrodruon urundeuva Fr. All. (Anacardiaceae) (aroeira plant) and its essential oil with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli from clinical isolates. Materials and methods: After identification of the chemical components by GC-MS, the antibacterial activity of the natural products and antibiotics was assessed by determining the minimal inhibitory concentration (MIC) using the microdilution method and concentrations ranging 8-512 mg/mL and 0.0012-2.5 mg/mL, respectively. Assays were performed to test for a possible synergistic action between the plant products and the antimicrobials, using the extract and the oil at a sub-inhibitory concentration (128 mg/mL) and antibiotic at concentrations varying between 8 and 512 mg/mL. Results: The GC-MS analysis identified the main compound as d-carene (80.41%). The MIC of the natural products was 41024 mg/mL, except against S. aureus ATCC25923. Only the combinations of the natural products with gentamicin, amikacin and clindamycin were effective against S. aureus 358, enhancing the antibiotic activity by reducing the MIC. Conclusions: The extract from aroeira showed a higher antibacterial activity and the oil was more effective in potentiating the activity of conventional antibiotics.

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“…It was reported that in Europe alone, 25,000 patients die annually because of bacterial infections which cannot be treated with common antibiotics (2). Examples of antibiotic-resistant bacteria are methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus spp., carbapenem-resistant Mycobacterium tuberculosis, and highly virulent multidrug-resistant Clostridium difficile strains (2)(3)(4)(5). Therefore, the discovery and development of new antimicrobial agents are of paramount importance.…”

mentioning

confidence: 99%

Isolation and Structural Elucidation of Brevibacillin, an Antimicrobial Lipopeptide from Brevibacillus laterosporus That Combats Drug-Resistant Gram-Positive Bacteria

Huang

Yuan

et al. 2016

Appl Environ Microbiol

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A new environmental bacterial strain exhibited strong antimicrobial characteristics against methicillin-resistant Staphylococcus aureus, vancomycin-resistant strains of Enterococcus faecalis and Lactobacillus plantarum, and other Gram-positive bacteria. The producer strain, designated OSY-I 1 , was determined to be Brevibacillus laterosporus via morphological, biochemical, and genetic analyses. The antimicrobial agent was extracted from cells of OSY-I 1 with isopropanol, purified by high-performance liquid chromatography, and structurally analyzed using mass spectrometry (MS) and nuclear magnetic resonance (NMR). The MS and NMR results, taken together, uncovered a linear lipopeptide consisting of 13 amino acids and an N-terminal C 6 fatty acid (FA) chain, 2-hydroxy-3-methylpentanoic acid. The lipopeptide (FA-Dhb-Leu-Orn-Ile-Ile-Val-Lys-Val-Val-Lys-Tyr-Leu-valinol, where Dhb is ␣,␤-didehydrobutyric acid and valinol is 2-amino-3-methyl-1-butanol) has a molecular mass of 1,583.0794 Da and contains three modified amino acid residues: ␣,␤-didehydrobutyric acid, ornithine, and valinol. The compound, designated brevibacillin, was determined to be a member of a cationic lipopeptide antibiotic family. In addition to its potency against drugresistant bacteria, brevibacillin also exhibited low MICs (1 to 8 g/ml) against selected foodborne pathogenic and spoilage bacteria, such as Listeria monocytogenes, Bacillus cereus, and Alicyclobacillus acidoterrestris. Purified brevibacillin showed no sign of degradation when it was held at 80°C for 60 min, and it retained at least 50% of its antimicrobial activity when it was held for 22 h under acidic or alkaline conditions. On the basis of these findings, brevibacillin is a potent antimicrobial lipopeptide which is potentially useful to combat drug-resistant bacterial pathogens and foodborne pathogenic and spoilage bacteria. U nregulated access to antibiotics is one of the main reasons for the spread of antibiotic-resistant pathogens and their resistance genes through migration, travel, and trade (1). It was reported that in Europe alone, 25,000 patients die annually because of bacterial infections which cannot be treated with common antibiotics (2). Examples of antibiotic-resistant bacteria are methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus spp., carbapenem-resistant Mycobacterium tuberculosis, and highly virulent multidrug-resistant Clostridium difficile strains (2-5). Therefore, the discovery and development of new antimicrobial agents are of paramount importance. Despite their natural scarcity, new antimicrobial agents can be discovered by subjecting microorganisms that potentially produce such agents to screening and isolation processes (6, 7).The current study led to the discovery of a new strain of Brevibacillus sp. with promising antimicrobial activity. The genus Brevibacillus was established in 1996 on the basis of a genetic reclassification of strains previously recognized to be Bacillus brevis (8). Many bioactive compounds have been...

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The global need for effective antibiotics—Moving towards concerted action

Cited by 87 publications

References 8 publications

In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Isolation and Structural Elucidation of Brevibacillin, an Antimicrobial Lipopeptide from Brevibacillus laterosporus That Combats Drug-Resistant Gram-Positive Bacteria

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