The global, regional, and national burden of tuberculosis in 204 countries and territories, 1990–2019

Zhang, Ting; Zhang, Jinyu; Li, Wei; Liang, Hongsen; Zhang, Junhang; Shi, Donglei; Wang, Zhaojun

doi:10.1016/j.jiph.2023.01.014

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…This case of disseminated TB in a middle-childhood boy migrating from Angola to France illustrates the complexities of diagnosing and managing TB, especially in paediatric cases and migrant populations. TB remains a major global health concern, with children accounting for a substantial portion of new cases and deaths 1–3. Confirming TB in children is challenging due to specimen collection difficulties and the paucibacillary nature of the disease, often delaying accurate diagnosis 4 5…”

Section: Discussionmentioning

confidence: 99%

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Disseminated tuberculosis in a migrant child

Boccard,

Corvol,

Prévost

et al. 2024

BMJ Case Rep

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Tuberculosis (TB) poses a major global health threat, substantially affecting children, who contribute notably to new cases and deaths. Diagnosing TB in kids is challenging due to collection issues and the paucibacillary nature of the disease. Disseminated TB, uncommon in children in low TB incidence countries, remains a significant cause of morbidity in migrant populations. We illustrate a rare case of disseminated TB in a middle-childhood boy who migrated from Angola to France, displaying chronic cough, fatigue, weight loss and persistent fever. Investigations revealed widespread TB affecting several organs (lungs, heart, bones and lymph nodes). Prompt diagnosis led to a treatment regimen of four antibiotics (isoniazid, rifampin, pyrazinamide, ethambutol) and corticosteroids, resulting in substantial improvement after 2 months. Subsequent treatment involved two antibiotics (isoniazid and rifampin) for 10 more months. This case underscores the criticality of early identification and comprehensive treatment for disseminated TB, ensuring improved outcomes and reduced risks.

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Section: Discussionmentioning

confidence: 99%

“…Tuberculosis (TB) is a significant public health concern, ranking among the top 15 causes of death worldwide 1 2. It is estimated that children account for approximately 12% of all new TB cases and approximately 16% of TB-related deaths 1 3.…”

Section: Introductionmentioning

confidence: 99%

Disseminated tuberculosis in a migrant child

Boccard,

Corvol,

Prévost

et al. 2024

BMJ Case Rep

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“…Mycobacterium tuberculosis ( Mtb ) is the causative agent of tuberculosis (TB) [1] . Tuberculosis (TB) is a persistent health problem that ranks as the 13th leading cause of death worldwide [2] ; since 2012, it has been the leading cause of death among infectious diseases. Despite numerous efforts, the control of TB remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria

Su,

Lai,

Tsai

et al. 2024

Computational and Structural Biotechnology Journal

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“…Tuberculosis (TB), caused by the bacillus Mycobacterium tuberculosis ( Mtb ), is a major public health concern today despite the prevalence of screening methods, vaccines, and the use of antibiotics. Although researchers have found that the number of deaths and those infected has continued to decrease over the past few decades, the immunocompromised and those in low-income countries continue to be the most at risk [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection

Vu,

Glassman,

Campbell

et al. 2024

IJMS

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Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a prevalent infectious disease affecting populations worldwide. A classic trait of TB pathology is the formation of granulomas, which wall off the pathogen, via the innate and adaptive immune systems. Some key players involved include tumor necrosis factor-alpha (TNF-α), foamy macrophages, type I interferons (IFNs), and reactive oxygen species, which may also show overlap with cell death pathways. Additionally, host cell death is a primary method for combating and controlling Mtb within the body, a process which is influenced by both host and bacterial factors. These cell death modalities have distinct molecular mechanisms and pathways. Programmed cell death (PCD), encompassing apoptosis and autophagy, typically confers a protective response against Mtb by containing the bacteria within dead macrophages, facilitating their phagocytosis by uninfected or neighboring cells, whereas necrotic cell death benefits the pathogen, leading to the release of bacteria extracellularly. Apoptosis is triggered via intrinsic and extrinsic caspase-dependent pathways as well as caspase-independent pathways. Necrosis is induced via various pathways, including necroptosis, pyroptosis, and ferroptosis. Given the pivotal role of host cell death pathways in host defense against Mtb, therapeutic agents targeting cell death signaling have been investigated for TB treatment. This review provides an overview of the diverse mechanisms underlying Mtb-induced host cell death, examining their implications for host immunity. Furthermore, it discusses the potential of targeting host cell death pathways as therapeutic and preventive strategies against Mtb infection.

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The global, regional, and national burden of tuberculosis in 204 countries and territories, 1990–2019

Cited by 9 publications

References 19 publications

Disseminated tuberculosis in a migrant child

Disseminated tuberculosis in a migrant child

Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria

Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection

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