The Glymphatic System Activity and Cognitive Declines in Healthy Old Adults

Uwisengeyimana, Jean de Dieu; Nguchu, Benedictor Alexander; Wang, Yanming; Zhang, Du; Liu, Yanpeng; Jiang, Zhoufan; Wang, Xiaoxiao; Qiu, Bensheng

doi:10.1109/icmipe53131.2021.9698892

Cited by 1 publication

(2 citation statements)

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“…For example, the DTI-ALPS method was extensively applied in aging and cSVD populations, where all studies found a negative relation between WMH load and venous ISF PVS diffusion. 58,[67][68][69][70] The inflammation in WMH increases the production of waste products and the accumulation of waste might in turn cause the ISF to flow slower along the PVS (i.e., DTI-ALPS-index closer to 1). 58 Potentially, the relation between WMHs and DTI-ALPS-indices could be biased by the inclusion of WMH or the WMH penumbra in the manually drawn region outside the lateral ventricle, where the DTI-ALPS-index is determined.…”

Section: Neurodegenerative Diseases Alzheimer's Diseasementioning

confidence: 99%

“…Several ISF‐related MRI measures were previously investigated in relation to WMH. For example, the DTI‐ALPS method was extensively applied in aging and cSVD populations, where all studies found a negative relation between WMH load and venous ISF PVS diffusion 58,67–70 . The inflammation in WMH increases the production of waste products and the accumulation of waste might in turn cause the ISF to flow slower along the PVS (i.e., DTI‐ALPS‐index closer to 1) 58 .…”

Section: Mri Techniquesmentioning

confidence: 99%

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Imaging Interstitial Fluid With MRI: A Narrative Review on the Associations of Altered Interstitial Fluid With Vascular and Neurodegenerative Abnormalities

Drenthen,

Elschot,

van der Knaap

et al. 2023

Magnetic Resonance Imaging

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Interstitial fluid (ISF) refers to the fluid between the parenchymal cells and along the perivascular spaces (PVS). ISF plays a crucial role in delivering nutrients and clearing waste products from the brain. This narrative review focuses on the use of MRI techniques to measure various ISF characteristics in humans. The complementary value of contrast‐enhanced and noncontrast‐enhanced techniques is highlighted. While contrast‐enhanced MRI methods allow measurement of ISF transport and flow, they lack quantitative assessment of ISF properties. Noninvasive MRI techniques, including multi‐b‐value diffusion imaging, free‐water‐imaging, T2‐decay imaging, and DTI along the PVS, offer promising alternatives to derive ISF measures, such as ISF volume and diffusivity. The emerging role of these MRI techniques in investigating ISF alterations in neurodegenerative diseases (eg, Alzheimer's disease and Parkinson's disease) and cerebrovascular diseases (eg, cerebral small vessel disease and stroke) is discussed. This review also emphasizes current challenges of ISF imaging, such as the microscopic scale at which ISF has to be measured, and discusses potential focus points for future research to overcome these challenges, for example, the use of high‐resolution imaging techniques. Noninvasive MRI methods for measuring ISF characteristics hold significant potential and may have a high clinical impact in understanding the pathophysiology of neurodegenerative and cerebrovascular disorders, as well as in evaluating the efficacy of ISF‐targeted therapies in clinical trials.Level of Evidence3Technical EfficacyStage 2

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