The Gore REDUCE Clinical Study

Abstract

The Gore REDUCE Clinical Study is a prospective, randomized, open-label, multinational, multicenter evaluation comparing antiplatelet medical management plus percutaneous paten foramen ovale device closure to antiplatelet medical management alone. Since the effi cacy of these treatment options in reducing the risk of recurrent cryptogenic stroke remains uncertain, the outcome of this clinical study will contribute to available data regarding this patient population. Our chapter reviews the REDUCE studies design elements that allow it to contribute new information relevant to the patent foramen ovale-stoke question.