The GPR30 Pathway Is Involved in Mediating the Estrogenic Effects of Ginsenoside RG1

Gao, Quan-Gui; Wong, Man Sau

doi:10.1210/endo-meetings.2011.part1.p8.p1-168

Cited by 1 publication

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“…The combined administration of Rg 1 and 5-FU can improve the efficacy of 5-FU obviously; the life extension is much higher than that of simple 5-FU group, and there is a statistical significance of difference (P<0.05), which means that Rg 1 can enhance the 5-FU's anti-tumor effect. This shows that the combined application of Rg 1 and traditional radiochemical therapeutic drugs can improve the latter's anti-tumor effect with certain synergism [14,15] . Zhang Jingwei, etc., find that Rg 1 can remove the 5-FU's side effect of cell immunodeficiency, as well as improve the organism immunity; it means that Rg 1 may remedy the CTX and 5-FU's side effect of immunosuppression, and strengthen the reactivity of mice bearing tumor towards tumor and outside stimulus.…”

Section: Discussionmentioning

confidence: 87%

Experimental study on growth inhibition against colon cancer of animal model by combined application of ginsenoside Rg1 and chemotherapeutic medicine

Chang

Yang

et al. 2011

Proceedings 2011 International Conference on Human Health and Biomedical Engineering

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Observe the inhibition of Rg 1 against the growth of colon cancer cell strains through dye exclusion experiment in vitro. In vivo, establish the colon cancer animal model, divide the mice bearing tumor into 6 groups randomly, i.e., Rg 1 3, 1, 0.3 mg·kg -1 groups, cyclophosphamide group (CTX), solvent control group, and combined administration group (CTX + Rg 1 ); administer drug into abdominal cavity daily for 10 days, kill the animals after stopping administration for 24h, weigh them and tumors, and calculate the tumor growth inhibition rate (%) and Coefficient of Drug Interaction (CDI). Additionally, establish the SW620 ascites tumor model, assign the animals into Rg 1 3, 1, 0.3 mg·kg -1 groups, 5-fluorouracil group (5-FU), solvent control group, and combined administration group (Rg 1 + 5-FU) randomly, administer drug into abdominal cavity daily for 5 days, record the mouse survival days, and calculate the life extension. Rg 1 can inhibit the growth of tumor significantly, and extend the survival time of mice bearing tumor; additionally, Rg 1 can improve the antitumor effect of CTX and 5-FU.

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Section: Discussionmentioning

confidence: 87%